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Correlation of clinical parameters with endolymphatic hydrops on MRI in Meniere's disease

A clinical diagnosis of Ménière's disease (MD) is made based on medical history and audiometry findings. The 1995 American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) guidelines requires histopathological confirmation of endolymphatic hydrops (EH) for a diagnosis of “certain” MD....

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Autores principales: Han, Seung Cheol, Kim, Young Seok, Kim, Yehree, Lee, Sang-Yeon, Song, Jae-Jin, Choi, Byung Yoon, Kim, Ji-Soo, Bae, Yun Jung, Koo, Ja-Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361122/
https://www.ncbi.nlm.nih.gov/pubmed/35959407
http://dx.doi.org/10.3389/fneur.2022.937703
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author Han, Seung Cheol
Kim, Young Seok
Kim, Yehree
Lee, Sang-Yeon
Song, Jae-Jin
Choi, Byung Yoon
Kim, Ji-Soo
Bae, Yun Jung
Koo, Ja-Won
author_facet Han, Seung Cheol
Kim, Young Seok
Kim, Yehree
Lee, Sang-Yeon
Song, Jae-Jin
Choi, Byung Yoon
Kim, Ji-Soo
Bae, Yun Jung
Koo, Ja-Won
author_sort Han, Seung Cheol
collection PubMed
description A clinical diagnosis of Ménière's disease (MD) is made based on medical history and audiometry findings. The 1995 American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) guidelines requires histopathological confirmation of endolymphatic hydrops (EH) for a diagnosis of “certain” MD. Symptoms such as dizziness and ear fullness are important diagnostic features; however, the descriptions provided by patients are frequently vague and non-specific. A recently developed magnetic resonance imaging (MRI) protocol to document EH is, therefore, useful for the evaluation of inner ear status in patients with MD. In this study, patients with MD were assessed using MRI and the HYDROPS (HYbriD of Reversed image Of Positive endolymph signal and native image of positive perilymph Signal) protocol to investigate the effectiveness of MRI for visualization of the endolymphatic space in the diagnosis of MD by correlating clinical laboratory parameters with the grade of EH. Of the 123 patients with MD recruited in this study, 80 had definite MD, 11 had probable MD, and 32 had possible MD based on the 1995 AAO-HNS guidelines. The EH grade based on HYDROPS MRI was determined independently by two otorhinolaryngologists and compared with several clinical parameters, including the diagnostic scale of MD (1995 AAO-HNS guidelines), pure tone average (PTA), low tone average (LTA), canal paresis (CP) on the caloric test, and disease duration. Cochlear hydrops and vestibular hydrops were detected in 58 and 80% of 80 definite MD ears, in 33 and 58% of 12 probable MD ears, and in 5 and 27% of 37 possible MD ears, respectively. The proportion of higher hydrops grades increased significantly with grade according to the MD diagnostic scale (p < 0.0001). Both PTA and LTA were significantly higher in patients with hydrops grade 2 than hydrops grade 0 in both the cochlea and the vestibule. CP was significantly higher in patients with grade 2 than grade 0 vestibular hydrops. Disease duration was not associated with hydrops grade. Radiological evaluation of MD using the HYDROPS protocol is useful for evaluation of the extent and severity of EH in the diagnosis of MD based on its pathophysiological mechanism.
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spelling pubmed-93611222022-08-10 Correlation of clinical parameters with endolymphatic hydrops on MRI in Meniere's disease Han, Seung Cheol Kim, Young Seok Kim, Yehree Lee, Sang-Yeon Song, Jae-Jin Choi, Byung Yoon Kim, Ji-Soo Bae, Yun Jung Koo, Ja-Won Front Neurol Neurology A clinical diagnosis of Ménière's disease (MD) is made based on medical history and audiometry findings. The 1995 American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) guidelines requires histopathological confirmation of endolymphatic hydrops (EH) for a diagnosis of “certain” MD. Symptoms such as dizziness and ear fullness are important diagnostic features; however, the descriptions provided by patients are frequently vague and non-specific. A recently developed magnetic resonance imaging (MRI) protocol to document EH is, therefore, useful for the evaluation of inner ear status in patients with MD. In this study, patients with MD were assessed using MRI and the HYDROPS (HYbriD of Reversed image Of Positive endolymph signal and native image of positive perilymph Signal) protocol to investigate the effectiveness of MRI for visualization of the endolymphatic space in the diagnosis of MD by correlating clinical laboratory parameters with the grade of EH. Of the 123 patients with MD recruited in this study, 80 had definite MD, 11 had probable MD, and 32 had possible MD based on the 1995 AAO-HNS guidelines. The EH grade based on HYDROPS MRI was determined independently by two otorhinolaryngologists and compared with several clinical parameters, including the diagnostic scale of MD (1995 AAO-HNS guidelines), pure tone average (PTA), low tone average (LTA), canal paresis (CP) on the caloric test, and disease duration. Cochlear hydrops and vestibular hydrops were detected in 58 and 80% of 80 definite MD ears, in 33 and 58% of 12 probable MD ears, and in 5 and 27% of 37 possible MD ears, respectively. The proportion of higher hydrops grades increased significantly with grade according to the MD diagnostic scale (p < 0.0001). Both PTA and LTA were significantly higher in patients with hydrops grade 2 than hydrops grade 0 in both the cochlea and the vestibule. CP was significantly higher in patients with grade 2 than grade 0 vestibular hydrops. Disease duration was not associated with hydrops grade. Radiological evaluation of MD using the HYDROPS protocol is useful for evaluation of the extent and severity of EH in the diagnosis of MD based on its pathophysiological mechanism. Frontiers Media S.A. 2022-07-25 /pmc/articles/PMC9361122/ /pubmed/35959407 http://dx.doi.org/10.3389/fneur.2022.937703 Text en Copyright © 2022 Han, Kim, Kim, Lee, Song, Choi, Kim, Bae and Koo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Han, Seung Cheol
Kim, Young Seok
Kim, Yehree
Lee, Sang-Yeon
Song, Jae-Jin
Choi, Byung Yoon
Kim, Ji-Soo
Bae, Yun Jung
Koo, Ja-Won
Correlation of clinical parameters with endolymphatic hydrops on MRI in Meniere's disease
title Correlation of clinical parameters with endolymphatic hydrops on MRI in Meniere's disease
title_full Correlation of clinical parameters with endolymphatic hydrops on MRI in Meniere's disease
title_fullStr Correlation of clinical parameters with endolymphatic hydrops on MRI in Meniere's disease
title_full_unstemmed Correlation of clinical parameters with endolymphatic hydrops on MRI in Meniere's disease
title_short Correlation of clinical parameters with endolymphatic hydrops on MRI in Meniere's disease
title_sort correlation of clinical parameters with endolymphatic hydrops on mri in meniere's disease
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361122/
https://www.ncbi.nlm.nih.gov/pubmed/35959407
http://dx.doi.org/10.3389/fneur.2022.937703
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