Cargando…
Correlation of clinical parameters with endolymphatic hydrops on MRI in Meniere's disease
A clinical diagnosis of Ménière's disease (MD) is made based on medical history and audiometry findings. The 1995 American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) guidelines requires histopathological confirmation of endolymphatic hydrops (EH) for a diagnosis of “certain” MD....
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361122/ https://www.ncbi.nlm.nih.gov/pubmed/35959407 http://dx.doi.org/10.3389/fneur.2022.937703 |
_version_ | 1784764464234496000 |
---|---|
author | Han, Seung Cheol Kim, Young Seok Kim, Yehree Lee, Sang-Yeon Song, Jae-Jin Choi, Byung Yoon Kim, Ji-Soo Bae, Yun Jung Koo, Ja-Won |
author_facet | Han, Seung Cheol Kim, Young Seok Kim, Yehree Lee, Sang-Yeon Song, Jae-Jin Choi, Byung Yoon Kim, Ji-Soo Bae, Yun Jung Koo, Ja-Won |
author_sort | Han, Seung Cheol |
collection | PubMed |
description | A clinical diagnosis of Ménière's disease (MD) is made based on medical history and audiometry findings. The 1995 American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) guidelines requires histopathological confirmation of endolymphatic hydrops (EH) for a diagnosis of “certain” MD. Symptoms such as dizziness and ear fullness are important diagnostic features; however, the descriptions provided by patients are frequently vague and non-specific. A recently developed magnetic resonance imaging (MRI) protocol to document EH is, therefore, useful for the evaluation of inner ear status in patients with MD. In this study, patients with MD were assessed using MRI and the HYDROPS (HYbriD of Reversed image Of Positive endolymph signal and native image of positive perilymph Signal) protocol to investigate the effectiveness of MRI for visualization of the endolymphatic space in the diagnosis of MD by correlating clinical laboratory parameters with the grade of EH. Of the 123 patients with MD recruited in this study, 80 had definite MD, 11 had probable MD, and 32 had possible MD based on the 1995 AAO-HNS guidelines. The EH grade based on HYDROPS MRI was determined independently by two otorhinolaryngologists and compared with several clinical parameters, including the diagnostic scale of MD (1995 AAO-HNS guidelines), pure tone average (PTA), low tone average (LTA), canal paresis (CP) on the caloric test, and disease duration. Cochlear hydrops and vestibular hydrops were detected in 58 and 80% of 80 definite MD ears, in 33 and 58% of 12 probable MD ears, and in 5 and 27% of 37 possible MD ears, respectively. The proportion of higher hydrops grades increased significantly with grade according to the MD diagnostic scale (p < 0.0001). Both PTA and LTA were significantly higher in patients with hydrops grade 2 than hydrops grade 0 in both the cochlea and the vestibule. CP was significantly higher in patients with grade 2 than grade 0 vestibular hydrops. Disease duration was not associated with hydrops grade. Radiological evaluation of MD using the HYDROPS protocol is useful for evaluation of the extent and severity of EH in the diagnosis of MD based on its pathophysiological mechanism. |
format | Online Article Text |
id | pubmed-9361122 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93611222022-08-10 Correlation of clinical parameters with endolymphatic hydrops on MRI in Meniere's disease Han, Seung Cheol Kim, Young Seok Kim, Yehree Lee, Sang-Yeon Song, Jae-Jin Choi, Byung Yoon Kim, Ji-Soo Bae, Yun Jung Koo, Ja-Won Front Neurol Neurology A clinical diagnosis of Ménière's disease (MD) is made based on medical history and audiometry findings. The 1995 American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) guidelines requires histopathological confirmation of endolymphatic hydrops (EH) for a diagnosis of “certain” MD. Symptoms such as dizziness and ear fullness are important diagnostic features; however, the descriptions provided by patients are frequently vague and non-specific. A recently developed magnetic resonance imaging (MRI) protocol to document EH is, therefore, useful for the evaluation of inner ear status in patients with MD. In this study, patients with MD were assessed using MRI and the HYDROPS (HYbriD of Reversed image Of Positive endolymph signal and native image of positive perilymph Signal) protocol to investigate the effectiveness of MRI for visualization of the endolymphatic space in the diagnosis of MD by correlating clinical laboratory parameters with the grade of EH. Of the 123 patients with MD recruited in this study, 80 had definite MD, 11 had probable MD, and 32 had possible MD based on the 1995 AAO-HNS guidelines. The EH grade based on HYDROPS MRI was determined independently by two otorhinolaryngologists and compared with several clinical parameters, including the diagnostic scale of MD (1995 AAO-HNS guidelines), pure tone average (PTA), low tone average (LTA), canal paresis (CP) on the caloric test, and disease duration. Cochlear hydrops and vestibular hydrops were detected in 58 and 80% of 80 definite MD ears, in 33 and 58% of 12 probable MD ears, and in 5 and 27% of 37 possible MD ears, respectively. The proportion of higher hydrops grades increased significantly with grade according to the MD diagnostic scale (p < 0.0001). Both PTA and LTA were significantly higher in patients with hydrops grade 2 than hydrops grade 0 in both the cochlea and the vestibule. CP was significantly higher in patients with grade 2 than grade 0 vestibular hydrops. Disease duration was not associated with hydrops grade. Radiological evaluation of MD using the HYDROPS protocol is useful for evaluation of the extent and severity of EH in the diagnosis of MD based on its pathophysiological mechanism. Frontiers Media S.A. 2022-07-25 /pmc/articles/PMC9361122/ /pubmed/35959407 http://dx.doi.org/10.3389/fneur.2022.937703 Text en Copyright © 2022 Han, Kim, Kim, Lee, Song, Choi, Kim, Bae and Koo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Han, Seung Cheol Kim, Young Seok Kim, Yehree Lee, Sang-Yeon Song, Jae-Jin Choi, Byung Yoon Kim, Ji-Soo Bae, Yun Jung Koo, Ja-Won Correlation of clinical parameters with endolymphatic hydrops on MRI in Meniere's disease |
title | Correlation of clinical parameters with endolymphatic hydrops on MRI in Meniere's disease |
title_full | Correlation of clinical parameters with endolymphatic hydrops on MRI in Meniere's disease |
title_fullStr | Correlation of clinical parameters with endolymphatic hydrops on MRI in Meniere's disease |
title_full_unstemmed | Correlation of clinical parameters with endolymphatic hydrops on MRI in Meniere's disease |
title_short | Correlation of clinical parameters with endolymphatic hydrops on MRI in Meniere's disease |
title_sort | correlation of clinical parameters with endolymphatic hydrops on mri in meniere's disease |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361122/ https://www.ncbi.nlm.nih.gov/pubmed/35959407 http://dx.doi.org/10.3389/fneur.2022.937703 |
work_keys_str_mv | AT hanseungcheol correlationofclinicalparameterswithendolymphatichydropsonmriinmenieresdisease AT kimyoungseok correlationofclinicalparameterswithendolymphatichydropsonmriinmenieresdisease AT kimyehree correlationofclinicalparameterswithendolymphatichydropsonmriinmenieresdisease AT leesangyeon correlationofclinicalparameterswithendolymphatichydropsonmriinmenieresdisease AT songjaejin correlationofclinicalparameterswithendolymphatichydropsonmriinmenieresdisease AT choibyungyoon correlationofclinicalparameterswithendolymphatichydropsonmriinmenieresdisease AT kimjisoo correlationofclinicalparameterswithendolymphatichydropsonmriinmenieresdisease AT baeyunjung correlationofclinicalparameterswithendolymphatichydropsonmriinmenieresdisease AT koojawon correlationofclinicalparameterswithendolymphatichydropsonmriinmenieresdisease |