Development of a novel peptide to prevent entry of SARS-CoV-2 into lung and olfactory bulb cells of hACE2 expressing mice

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus that has caused a global pandemic Coronavirus Disease 2019 (COVID-19). Currently, there are no effective treatments specifically for COVID-19 infection. The initial step in SARS-CoV-2 infection is attachment to the a...

Descripción completa

Detalles Bibliográficos
Autores principales: Su, Ping, Zhai, Dongxu, Wong, Albert H. C., Liu, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361269/
https://www.ncbi.nlm.nih.gov/pubmed/35945596
http://dx.doi.org/10.1186/s13041-022-00956-1
_version_ 1784764496471916544
author Su, Ping
Zhai, Dongxu
Wong, Albert H. C.
Liu, Fang
author_facet Su, Ping
Zhai, Dongxu
Wong, Albert H. C.
Liu, Fang
author_sort Su, Ping
collection PubMed
description Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus that has caused a global pandemic Coronavirus Disease 2019 (COVID-19). Currently, there are no effective treatments specifically for COVID-19 infection. The initial step in SARS-CoV-2 infection is attachment to the angiotensin-converting enzyme 2 (ACE2) on the cell surface. We have developed a protein peptide that effectively disrupts the binding between the SARS-CoV-2 spike protein and ACE2. When delivered by nasal spray, our peptide prevents SARS-CoV-2 spike protein from entering lung and olfactory bulb cells of mice expressing human ACE2. Our peptide represents a potential novel treatment and prophylaxis against COVID-19. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13041-022-00956-1.
format Online
Article
Text
id pubmed-9361269
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-93612692022-08-09 Development of a novel peptide to prevent entry of SARS-CoV-2 into lung and olfactory bulb cells of hACE2 expressing mice Su, Ping Zhai, Dongxu Wong, Albert H. C. Liu, Fang Mol Brain Research Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus that has caused a global pandemic Coronavirus Disease 2019 (COVID-19). Currently, there are no effective treatments specifically for COVID-19 infection. The initial step in SARS-CoV-2 infection is attachment to the angiotensin-converting enzyme 2 (ACE2) on the cell surface. We have developed a protein peptide that effectively disrupts the binding between the SARS-CoV-2 spike protein and ACE2. When delivered by nasal spray, our peptide prevents SARS-CoV-2 spike protein from entering lung and olfactory bulb cells of mice expressing human ACE2. Our peptide represents a potential novel treatment and prophylaxis against COVID-19. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13041-022-00956-1. BioMed Central 2022-08-09 /pmc/articles/PMC9361269/ /pubmed/35945596 http://dx.doi.org/10.1186/s13041-022-00956-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Su, Ping
Zhai, Dongxu
Wong, Albert H. C.
Liu, Fang
Development of a novel peptide to prevent entry of SARS-CoV-2 into lung and olfactory bulb cells of hACE2 expressing mice
title Development of a novel peptide to prevent entry of SARS-CoV-2 into lung and olfactory bulb cells of hACE2 expressing mice
title_full Development of a novel peptide to prevent entry of SARS-CoV-2 into lung and olfactory bulb cells of hACE2 expressing mice
title_fullStr Development of a novel peptide to prevent entry of SARS-CoV-2 into lung and olfactory bulb cells of hACE2 expressing mice
title_full_unstemmed Development of a novel peptide to prevent entry of SARS-CoV-2 into lung and olfactory bulb cells of hACE2 expressing mice
title_short Development of a novel peptide to prevent entry of SARS-CoV-2 into lung and olfactory bulb cells of hACE2 expressing mice
title_sort development of a novel peptide to prevent entry of sars-cov-2 into lung and olfactory bulb cells of hace2 expressing mice
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361269/
https://www.ncbi.nlm.nih.gov/pubmed/35945596
http://dx.doi.org/10.1186/s13041-022-00956-1
work_keys_str_mv AT suping developmentofanovelpeptidetoprevententryofsarscov2intolungandolfactorybulbcellsofhace2expressingmice
AT zhaidongxu developmentofanovelpeptidetoprevententryofsarscov2intolungandolfactorybulbcellsofhace2expressingmice
AT wongalberthc developmentofanovelpeptidetoprevententryofsarscov2intolungandolfactorybulbcellsofhace2expressingmice
AT liufang developmentofanovelpeptidetoprevententryofsarscov2intolungandolfactorybulbcellsofhace2expressingmice

Ejemplares similares