Quick Access to Nucleobase-Modified Phosphoramidites for the Synthesis of Oligoribonucleotides Containing Post-Transcriptional Modifications and Epitranscriptomic Marks

[Image: see text] Herein, we report a straightforward one-step procedure for modifying N-nucleophilic groups in the nucleobases of commercially available nucleoside phosphoramidites. This method involves the deprotonation of amide groups under phase-transfer conditions and subsequent reaction with e...

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Detalles Bibliográficos
Autores principales: Ziemkiewicz, Kamil, Warminski, Marcin, Wojcik, Radoslaw, Kowalska, Joanna, Jemielity, Jacek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361293/
https://www.ncbi.nlm.nih.gov/pubmed/35857285
http://dx.doi.org/10.1021/acs.joc.2c01390

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361293/
https://www.ncbi.nlm.nih.gov/pubmed/35857285
http://dx.doi.org/10.1021/acs.joc.2c01390

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