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Quick Access to Nucleobase-Modified Phosphoramidites for the Synthesis of Oligoribonucleotides Containing Post-Transcriptional Modifications and Epitranscriptomic Marks
[Image: see text] Herein, we report a straightforward one-step procedure for modifying N-nucleophilic groups in the nucleobases of commercially available nucleoside phosphoramidites. This method involves the deprotonation of amide groups under phase-transfer conditions and subsequent reaction with e...
Autores principales: | Ziemkiewicz, Kamil, Warminski, Marcin, Wojcik, Radoslaw, Kowalska, Joanna, Jemielity, Jacek |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361293/ https://www.ncbi.nlm.nih.gov/pubmed/35857285 http://dx.doi.org/10.1021/acs.joc.2c01390 |
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