Visible Light-Driven Reductive Azaarylation of Coumarin-3-carboxylic Acids

[Image: see text] In the manuscript, reductive and decarboxylative azaarylation of coumarin-3-carboxylic acids is described. It utilizes the photocatalytic activation of (cyano)azaarenes in the presence of fac-Ir(ppy)(3) as a photocatalyst. The methodology is versatile and provides access to biologi...

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Autores principales: Kowalska, Ewelina, Artelska, Angelika, Albrecht, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361294/
https://www.ncbi.nlm.nih.gov/pubmed/35820401
http://dx.doi.org/10.1021/acs.joc.2c00683
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author Kowalska, Ewelina
Artelska, Angelika
Albrecht, Anna
author_facet Kowalska, Ewelina
Artelska, Angelika
Albrecht, Anna
author_sort Kowalska, Ewelina
collection PubMed
description [Image: see text] In the manuscript, reductive and decarboxylative azaarylation of coumarin-3-carboxylic acids is described. It utilizes the photocatalytic activation of (cyano)azaarenes in the presence of fac-Ir(ppy)(3) as a photocatalyst. The methodology is versatile and provides access to biologically relevant 4-substituted-chroman-2-ones. Visible light, photoredox catalyst, base, anhydrous solvent, and inert atmosphere constitute key parameters for the success of the described strategy. The developed methodology involves a wide range of coumarin-3-carboxylic acids as well as (cyano)azaarenes.
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spelling pubmed-93612942022-08-10 Visible Light-Driven Reductive Azaarylation of Coumarin-3-carboxylic Acids Kowalska, Ewelina Artelska, Angelika Albrecht, Anna J Org Chem [Image: see text] In the manuscript, reductive and decarboxylative azaarylation of coumarin-3-carboxylic acids is described. It utilizes the photocatalytic activation of (cyano)azaarenes in the presence of fac-Ir(ppy)(3) as a photocatalyst. The methodology is versatile and provides access to biologically relevant 4-substituted-chroman-2-ones. Visible light, photoredox catalyst, base, anhydrous solvent, and inert atmosphere constitute key parameters for the success of the described strategy. The developed methodology involves a wide range of coumarin-3-carboxylic acids as well as (cyano)azaarenes. American Chemical Society 2022-07-12 2022-08-05 /pmc/articles/PMC9361294/ /pubmed/35820401 http://dx.doi.org/10.1021/acs.joc.2c00683 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Kowalska, Ewelina
Artelska, Angelika
Albrecht, Anna
Visible Light-Driven Reductive Azaarylation of Coumarin-3-carboxylic Acids
title Visible Light-Driven Reductive Azaarylation of Coumarin-3-carboxylic Acids
title_full Visible Light-Driven Reductive Azaarylation of Coumarin-3-carboxylic Acids
title_fullStr Visible Light-Driven Reductive Azaarylation of Coumarin-3-carboxylic Acids
title_full_unstemmed Visible Light-Driven Reductive Azaarylation of Coumarin-3-carboxylic Acids
title_short Visible Light-Driven Reductive Azaarylation of Coumarin-3-carboxylic Acids
title_sort visible light-driven reductive azaarylation of coumarin-3-carboxylic acids
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361294/
https://www.ncbi.nlm.nih.gov/pubmed/35820401
http://dx.doi.org/10.1021/acs.joc.2c00683
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