Acute promyelocytic leukemia in a long-standing HIV-positive patient: Case report and literature review

The use of antiretroviral therapy has drastically improved the life quality and prognosis of people living with the human immunodeficiency virus (HIV). The risk of acute myeloid leukemia (AML) currently does not appear to be significantly increased compared to the general population. Acute promyeloc...

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Detalles Bibliográficos
Autores principales: Mendes-de-Almeida, Daniela P., Fernandez, Teresa de Souza, Lovatel, Viviane Lamim, da Rocha, Moises Martins, Gomes, Bernadete Evangelho, Monte-Mór, Bárbara C.R., Vianna, Danielle Tavares, Alcoforado, Marília T.G., Kronemberg, João Marcello P.B., Cardoso, João Pedro S.C., Oliveira, Vanessa da Gama, Bokel, Joanna, Vizzoni, Alexandre G., Nunes, Estevão Portela, Grinsztejn, Beatriz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361310/
https://www.ncbi.nlm.nih.gov/pubmed/35958242
http://dx.doi.org/10.1016/j.lrr.2022.100339
Descripción
Sumario:The use of antiretroviral therapy has drastically improved the life quality and prognosis of people living with the human immunodeficiency virus (HIV). The risk of acute myeloid leukemia (AML) currently does not appear to be significantly increased compared to the general population. Acute promyelocytic leukemia (APL), infrequent in people with HIV, is a distinct subtype of AML with unique molecular pathogenesis, clinical manifestations, and treatment. Herein we describe a fatal case of APL hypogranular variant in an HIV-positive patient presenting with hyperleukocytosis. Also, we conducted a literature review of the ten cases reported so far.

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