Acute promyelocytic leukemia in a long-standing HIV-positive patient: Case report and literature review

The use of antiretroviral therapy has drastically improved the life quality and prognosis of people living with the human immunodeficiency virus (HIV). The risk of acute myeloid leukemia (AML) currently does not appear to be significantly increased compared to the general population. Acute promyeloc...

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Autores principales: Mendes-de-Almeida, Daniela P., Fernandez, Teresa de Souza, Lovatel, Viviane Lamim, da Rocha, Moises Martins, Gomes, Bernadete Evangelho, Monte-Mór, Bárbara C.R., Vianna, Danielle Tavares, Alcoforado, Marília T.G., Kronemberg, João Marcello P.B., Cardoso, João Pedro S.C., Oliveira, Vanessa da Gama, Bokel, Joanna, Vizzoni, Alexandre G., Nunes, Estevão Portela, Grinsztejn, Beatriz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361310/
https://www.ncbi.nlm.nih.gov/pubmed/35958242
http://dx.doi.org/10.1016/j.lrr.2022.100339
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author Mendes-de-Almeida, Daniela P.
Fernandez, Teresa de Souza
Lovatel, Viviane Lamim
da Rocha, Moises Martins
Gomes, Bernadete Evangelho
Monte-Mór, Bárbara C.R.
Vianna, Danielle Tavares
Alcoforado, Marília T.G.
Kronemberg, João Marcello P.B.
Cardoso, João Pedro S.C.
Oliveira, Vanessa da Gama
Bokel, Joanna
Vizzoni, Alexandre G.
Nunes, Estevão Portela
Grinsztejn, Beatriz
author_facet Mendes-de-Almeida, Daniela P.
Fernandez, Teresa de Souza
Lovatel, Viviane Lamim
da Rocha, Moises Martins
Gomes, Bernadete Evangelho
Monte-Mór, Bárbara C.R.
Vianna, Danielle Tavares
Alcoforado, Marília T.G.
Kronemberg, João Marcello P.B.
Cardoso, João Pedro S.C.
Oliveira, Vanessa da Gama
Bokel, Joanna
Vizzoni, Alexandre G.
Nunes, Estevão Portela
Grinsztejn, Beatriz
author_sort Mendes-de-Almeida, Daniela P.
collection PubMed
description The use of antiretroviral therapy has drastically improved the life quality and prognosis of people living with the human immunodeficiency virus (HIV). The risk of acute myeloid leukemia (AML) currently does not appear to be significantly increased compared to the general population. Acute promyelocytic leukemia (APL), infrequent in people with HIV, is a distinct subtype of AML with unique molecular pathogenesis, clinical manifestations, and treatment. Herein we describe a fatal case of APL hypogranular variant in an HIV-positive patient presenting with hyperleukocytosis. Also, we conducted a literature review of the ten cases reported so far.
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spelling pubmed-93613102022-08-10 Acute promyelocytic leukemia in a long-standing HIV-positive patient: Case report and literature review Mendes-de-Almeida, Daniela P. Fernandez, Teresa de Souza Lovatel, Viviane Lamim da Rocha, Moises Martins Gomes, Bernadete Evangelho Monte-Mór, Bárbara C.R. Vianna, Danielle Tavares Alcoforado, Marília T.G. Kronemberg, João Marcello P.B. Cardoso, João Pedro S.C. Oliveira, Vanessa da Gama Bokel, Joanna Vizzoni, Alexandre G. Nunes, Estevão Portela Grinsztejn, Beatriz Leuk Res Rep Article The use of antiretroviral therapy has drastically improved the life quality and prognosis of people living with the human immunodeficiency virus (HIV). The risk of acute myeloid leukemia (AML) currently does not appear to be significantly increased compared to the general population. Acute promyelocytic leukemia (APL), infrequent in people with HIV, is a distinct subtype of AML with unique molecular pathogenesis, clinical manifestations, and treatment. Herein we describe a fatal case of APL hypogranular variant in an HIV-positive patient presenting with hyperleukocytosis. Also, we conducted a literature review of the ten cases reported so far. Elsevier 2022-07-26 /pmc/articles/PMC9361310/ /pubmed/35958242 http://dx.doi.org/10.1016/j.lrr.2022.100339 Text en © 2022 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Mendes-de-Almeida, Daniela P.
Fernandez, Teresa de Souza
Lovatel, Viviane Lamim
da Rocha, Moises Martins
Gomes, Bernadete Evangelho
Monte-Mór, Bárbara C.R.
Vianna, Danielle Tavares
Alcoforado, Marília T.G.
Kronemberg, João Marcello P.B.
Cardoso, João Pedro S.C.
Oliveira, Vanessa da Gama
Bokel, Joanna
Vizzoni, Alexandre G.
Nunes, Estevão Portela
Grinsztejn, Beatriz
Acute promyelocytic leukemia in a long-standing HIV-positive patient: Case report and literature review
title Acute promyelocytic leukemia in a long-standing HIV-positive patient: Case report and literature review
title_full Acute promyelocytic leukemia in a long-standing HIV-positive patient: Case report and literature review
title_fullStr Acute promyelocytic leukemia in a long-standing HIV-positive patient: Case report and literature review
title_full_unstemmed Acute promyelocytic leukemia in a long-standing HIV-positive patient: Case report and literature review
title_short Acute promyelocytic leukemia in a long-standing HIV-positive patient: Case report and literature review
title_sort acute promyelocytic leukemia in a long-standing hiv-positive patient: case report and literature review
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361310/
https://www.ncbi.nlm.nih.gov/pubmed/35958242
http://dx.doi.org/10.1016/j.lrr.2022.100339
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