Green-Emitting 4,5-Diaminonaphthalimides in Activity-Based Probes for the Detection of Thrombin

[Image: see text] The natures of electron-donating groups as well as the bridge between them determine the fate of substituted 1,8-naphthalimide molecules in the excited state. An activity-based probe constructed from a selective peptide sequence, a reactive warhead, and the brightest green-emitting...

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Detalles Bibliográficos
Autores principales: Krzeszewski, Maciej, Modrzycka, Sylwia, Bousquet, Manon H. E., Jacquemin, Denis, Drąg, Marcin, Gryko, Daniel T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361357/
https://www.ncbi.nlm.nih.gov/pubmed/35863755
http://dx.doi.org/10.1021/acs.orglett.2c02320
Descripción
Sumario:[Image: see text] The natures of electron-donating groups as well as the bridge between them determine the fate of substituted 1,8-naphthalimide molecules in the excited state. An activity-based probe constructed from a selective peptide sequence, a reactive warhead, and the brightest green-emitting fluorophore displays impressive performance for thrombin protease detection in a newly constructed series of 1,8-naphthalimides.

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