Green-Emitting 4,5-Diaminonaphthalimides in Activity-Based Probes for the Detection of Thrombin

[Image: see text] The natures of electron-donating groups as well as the bridge between them determine the fate of substituted 1,8-naphthalimide molecules in the excited state. An activity-based probe constructed from a selective peptide sequence, a reactive warhead, and the brightest green-emitting...

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Autores principales: Krzeszewski, Maciej, Modrzycka, Sylwia, Bousquet, Manon H. E., Jacquemin, Denis, Drąg, Marcin, Gryko, Daniel T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361357/
https://www.ncbi.nlm.nih.gov/pubmed/35863755
http://dx.doi.org/10.1021/acs.orglett.2c02320
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author Krzeszewski, Maciej
Modrzycka, Sylwia
Bousquet, Manon H. E.
Jacquemin, Denis
Drąg, Marcin
Gryko, Daniel T.
author_facet Krzeszewski, Maciej
Modrzycka, Sylwia
Bousquet, Manon H. E.
Jacquemin, Denis
Drąg, Marcin
Gryko, Daniel T.
author_sort Krzeszewski, Maciej
collection PubMed
description [Image: see text] The natures of electron-donating groups as well as the bridge between them determine the fate of substituted 1,8-naphthalimide molecules in the excited state. An activity-based probe constructed from a selective peptide sequence, a reactive warhead, and the brightest green-emitting fluorophore displays impressive performance for thrombin protease detection in a newly constructed series of 1,8-naphthalimides.
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spelling pubmed-93613572022-08-10 Green-Emitting 4,5-Diaminonaphthalimides in Activity-Based Probes for the Detection of Thrombin Krzeszewski, Maciej Modrzycka, Sylwia Bousquet, Manon H. E. Jacquemin, Denis Drąg, Marcin Gryko, Daniel T. Org Lett [Image: see text] The natures of electron-donating groups as well as the bridge between them determine the fate of substituted 1,8-naphthalimide molecules in the excited state. An activity-based probe constructed from a selective peptide sequence, a reactive warhead, and the brightest green-emitting fluorophore displays impressive performance for thrombin protease detection in a newly constructed series of 1,8-naphthalimides. American Chemical Society 2022-07-21 2022-08-05 /pmc/articles/PMC9361357/ /pubmed/35863755 http://dx.doi.org/10.1021/acs.orglett.2c02320 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Krzeszewski, Maciej
Modrzycka, Sylwia
Bousquet, Manon H. E.
Jacquemin, Denis
Drąg, Marcin
Gryko, Daniel T.
Green-Emitting 4,5-Diaminonaphthalimides in Activity-Based Probes for the Detection of Thrombin
title Green-Emitting 4,5-Diaminonaphthalimides in Activity-Based Probes for the Detection of Thrombin
title_full Green-Emitting 4,5-Diaminonaphthalimides in Activity-Based Probes for the Detection of Thrombin
title_fullStr Green-Emitting 4,5-Diaminonaphthalimides in Activity-Based Probes for the Detection of Thrombin
title_full_unstemmed Green-Emitting 4,5-Diaminonaphthalimides in Activity-Based Probes for the Detection of Thrombin
title_short Green-Emitting 4,5-Diaminonaphthalimides in Activity-Based Probes for the Detection of Thrombin
title_sort green-emitting 4,5-diaminonaphthalimides in activity-based probes for the detection of thrombin
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361357/
https://www.ncbi.nlm.nih.gov/pubmed/35863755
http://dx.doi.org/10.1021/acs.orglett.2c02320
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