PROTACs bearing piperazine-containing linkers: what effect on their protonation state?

Proteolysis targeting chimeras (PROTACs) represent an emerging class of compounds for innovative therapeutic application. Their bifunctional nature induces the formation of a ternary complex (target protein/PROTAC/E3 ligase) which allows target protein ubiquitination and subsequent proteasomal-depen...

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Detalles Bibliográficos
Autores principales: Desantis, Jenny, Mammoli, Andrea, Eleuteri, Michela, Coletti, Alice, Croci, Federico, Macchiarulo, Antonio, Goracci, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361468/
https://www.ncbi.nlm.nih.gov/pubmed/36043064
http://dx.doi.org/10.1039/d2ra03761k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361468/
https://www.ncbi.nlm.nih.gov/pubmed/36043064
http://dx.doi.org/10.1039/d2ra03761k

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