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DMRT Transcription Factors in the Control of Nervous System Sexual Differentiation

Sexual phenotypic differences in the nervous system are one of the most prevalent features across the animal kingdom. The molecular mechanisms responsible for sexual dimorphism throughout metazoan nervous systems are extremely diverse, ranging from intrinsic cell autonomous mechanisms to gonad-depen...

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Detalles Bibliográficos
Autores principales: Casado-Navarro, Rafael, Serrano-Saiz, Esther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361473/
https://www.ncbi.nlm.nih.gov/pubmed/35958734
http://dx.doi.org/10.3389/fnana.2022.937596
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author Casado-Navarro, Rafael
Serrano-Saiz, Esther
author_facet Casado-Navarro, Rafael
Serrano-Saiz, Esther
author_sort Casado-Navarro, Rafael
collection PubMed
description Sexual phenotypic differences in the nervous system are one of the most prevalent features across the animal kingdom. The molecular mechanisms responsible for sexual dimorphism throughout metazoan nervous systems are extremely diverse, ranging from intrinsic cell autonomous mechanisms to gonad-dependent endocrine control of sexual traits, or even extrinsic environmental cues. In recent years, the DMRT ancient family of transcription factors has emerged as being central in the development of sex-specific differentiation in all animals in which they have been studied. In this review, we provide an overview of the function of Dmrt genes in nervous system sexual regulation from an evolutionary perspective.
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spelling pubmed-93614732022-08-10 DMRT Transcription Factors in the Control of Nervous System Sexual Differentiation Casado-Navarro, Rafael Serrano-Saiz, Esther Front Neuroanat Neuroscience Sexual phenotypic differences in the nervous system are one of the most prevalent features across the animal kingdom. The molecular mechanisms responsible for sexual dimorphism throughout metazoan nervous systems are extremely diverse, ranging from intrinsic cell autonomous mechanisms to gonad-dependent endocrine control of sexual traits, or even extrinsic environmental cues. In recent years, the DMRT ancient family of transcription factors has emerged as being central in the development of sex-specific differentiation in all animals in which they have been studied. In this review, we provide an overview of the function of Dmrt genes in nervous system sexual regulation from an evolutionary perspective. Frontiers Media S.A. 2022-07-26 /pmc/articles/PMC9361473/ /pubmed/35958734 http://dx.doi.org/10.3389/fnana.2022.937596 Text en Copyright © 2022 Casado-Navarro and Serrano-Saiz. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Casado-Navarro, Rafael
Serrano-Saiz, Esther
DMRT Transcription Factors in the Control of Nervous System Sexual Differentiation
title DMRT Transcription Factors in the Control of Nervous System Sexual Differentiation
title_full DMRT Transcription Factors in the Control of Nervous System Sexual Differentiation
title_fullStr DMRT Transcription Factors in the Control of Nervous System Sexual Differentiation
title_full_unstemmed DMRT Transcription Factors in the Control of Nervous System Sexual Differentiation
title_short DMRT Transcription Factors in the Control of Nervous System Sexual Differentiation
title_sort dmrt transcription factors in the control of nervous system sexual differentiation
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361473/
https://www.ncbi.nlm.nih.gov/pubmed/35958734
http://dx.doi.org/10.3389/fnana.2022.937596
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