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The magnitude and perceived reasons for childhood cancer treatment abandonment in Ethiopia: from health care providers’ perspective
BACKGROUND: Treatment abandonment is one of major reasons for childhood cancer treatment failure and low survival rate in low- and middle-income countries. Ethiopia plans to reduce abandonment rate by 60% (2019–2023), but baseline data and information about the contextual risk factors that influence...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361525/ https://www.ncbi.nlm.nih.gov/pubmed/35941600 http://dx.doi.org/10.1186/s12913-022-08188-8 |
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author | Mirutse, Mizan Kiros Tolla, Mieraf Taddesse Memirie, Solomon Tessema Palm, Michael Tekle Hailu, Daniel Abdi, Kunuz Abdella Buli, Ermias Dessie Norheim, Ole F. |
author_facet | Mirutse, Mizan Kiros Tolla, Mieraf Taddesse Memirie, Solomon Tessema Palm, Michael Tekle Hailu, Daniel Abdi, Kunuz Abdella Buli, Ermias Dessie Norheim, Ole F. |
author_sort | Mirutse, Mizan Kiros |
collection | PubMed |
description | BACKGROUND: Treatment abandonment is one of major reasons for childhood cancer treatment failure and low survival rate in low- and middle-income countries. Ethiopia plans to reduce abandonment rate by 60% (2019–2023), but baseline data and information about the contextual risk factors that influence treatment abandonment are scarce. METHODS: This cross-sectional study was conducted from September 5 to 22, 2021, on the three major pediatric oncology centers in Ethiopia. Data on the incidence and reasons for treatment abandonment were obtained from healthcare professionals. We were unable to obtain data about the patients’ or guardians’ perspective because the information available in the cancer registry was incomplete to contact adequate number of respondents. We used a validated, semi-structured questionnaire developed by the International Society of Pediatric Oncology Abandonment Technical Working Group. We included all (N = 38) health care professionals (physicians, nurses, and social workers) working at these centers who had more than one year of experience in childhood cancer service provision (a universal sampling and 100% response rate). RESULTS: The perceived mean abandonment rate in Ethiopia is 34% (SE 2.5%). The risk of treatment abandonment is dependent on the type of cancer (high for bone sarcoma and brain tumor), the phase of treatment and treatment outcome. The highest risk is during maintenance and treatment failure or relapse for acute lymphoblastic leukemia, and during pre- or post-surgical phase for Wilms tumor and bone sarcoma. The major influencing risk factors in Ethiopia includes high cost of care, low economic status, long travel time to treatment centers, long waiting time, belief in the incurability of cancer and poor public awareness about childhood cancer. CONCLUSIONS: The perceived abandonment rate in Ethiopia is high, and the risk of abandonment varies according to the type of cancer, phase of treatment or treatment outcome. Therefore, mitigation strategies to reduce the abandonment rate should include identifying specific risk factors and prioritizing strategies based on their level of influence, effectiveness, feasibility, and affordability. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12913-022-08188-8. |
format | Online Article Text |
id | pubmed-9361525 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-93615252022-08-10 The magnitude and perceived reasons for childhood cancer treatment abandonment in Ethiopia: from health care providers’ perspective Mirutse, Mizan Kiros Tolla, Mieraf Taddesse Memirie, Solomon Tessema Palm, Michael Tekle Hailu, Daniel Abdi, Kunuz Abdella Buli, Ermias Dessie Norheim, Ole F. BMC Health Serv Res Research BACKGROUND: Treatment abandonment is one of major reasons for childhood cancer treatment failure and low survival rate in low- and middle-income countries. Ethiopia plans to reduce abandonment rate by 60% (2019–2023), but baseline data and information about the contextual risk factors that influence treatment abandonment are scarce. METHODS: This cross-sectional study was conducted from September 5 to 22, 2021, on the three major pediatric oncology centers in Ethiopia. Data on the incidence and reasons for treatment abandonment were obtained from healthcare professionals. We were unable to obtain data about the patients’ or guardians’ perspective because the information available in the cancer registry was incomplete to contact adequate number of respondents. We used a validated, semi-structured questionnaire developed by the International Society of Pediatric Oncology Abandonment Technical Working Group. We included all (N = 38) health care professionals (physicians, nurses, and social workers) working at these centers who had more than one year of experience in childhood cancer service provision (a universal sampling and 100% response rate). RESULTS: The perceived mean abandonment rate in Ethiopia is 34% (SE 2.5%). The risk of treatment abandonment is dependent on the type of cancer (high for bone sarcoma and brain tumor), the phase of treatment and treatment outcome. The highest risk is during maintenance and treatment failure or relapse for acute lymphoblastic leukemia, and during pre- or post-surgical phase for Wilms tumor and bone sarcoma. The major influencing risk factors in Ethiopia includes high cost of care, low economic status, long travel time to treatment centers, long waiting time, belief in the incurability of cancer and poor public awareness about childhood cancer. CONCLUSIONS: The perceived abandonment rate in Ethiopia is high, and the risk of abandonment varies according to the type of cancer, phase of treatment or treatment outcome. Therefore, mitigation strategies to reduce the abandonment rate should include identifying specific risk factors and prioritizing strategies based on their level of influence, effectiveness, feasibility, and affordability. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12913-022-08188-8. BioMed Central 2022-08-08 /pmc/articles/PMC9361525/ /pubmed/35941600 http://dx.doi.org/10.1186/s12913-022-08188-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Mirutse, Mizan Kiros Tolla, Mieraf Taddesse Memirie, Solomon Tessema Palm, Michael Tekle Hailu, Daniel Abdi, Kunuz Abdella Buli, Ermias Dessie Norheim, Ole F. The magnitude and perceived reasons for childhood cancer treatment abandonment in Ethiopia: from health care providers’ perspective |
title | The magnitude and perceived reasons for childhood cancer treatment abandonment in Ethiopia: from health care providers’ perspective |
title_full | The magnitude and perceived reasons for childhood cancer treatment abandonment in Ethiopia: from health care providers’ perspective |
title_fullStr | The magnitude and perceived reasons for childhood cancer treatment abandonment in Ethiopia: from health care providers’ perspective |
title_full_unstemmed | The magnitude and perceived reasons for childhood cancer treatment abandonment in Ethiopia: from health care providers’ perspective |
title_short | The magnitude and perceived reasons for childhood cancer treatment abandonment in Ethiopia: from health care providers’ perspective |
title_sort | magnitude and perceived reasons for childhood cancer treatment abandonment in ethiopia: from health care providers’ perspective |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361525/ https://www.ncbi.nlm.nih.gov/pubmed/35941600 http://dx.doi.org/10.1186/s12913-022-08188-8 |
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