Multi-omics analyses of MEN1 missense mutations identify disruption of menin–MLL and menin–JunD interactions as critical requirements for molecular pathogenicity

BACKGROUND: Loss-of-function mutations of the multiple endocrine neoplasia type 1 (MEN1) gene are causal to the MEN1 tumor syndrome, but they are also commonly found in sporadic pancreatic neuroendocrine tumors and other types of cancers. The MEN1 gene product, menin, is involved in transcriptional...

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Detalles Bibliográficos
Autores principales: Dreijerink, Koen M. A., Ozyerli-Goknar, Ezgi, Koidl, Stefanie, van der Lelij, Ewoud J., van den Heuvel, Priscilla, Kooijman, Jeffrey J., Biniossek, Martin L., Rodenburg, Kees W., Nizamuddin, Sheikh, Timmers, H. T. Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361535/
https://www.ncbi.nlm.nih.gov/pubmed/35941657
http://dx.doi.org/10.1186/s13072-022-00461-8

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