Single-cell diploid Hi-C reveals the role of spatial aggregations in complex rearrangements and KMT2A fusions in leukemia

BACKGROUND: Simple translocations and complex rearrangements are formed through illegitimate ligations of double-strand breaks of fusion partners and lead to generation of oncogenic fusion genes that affect cellular function. The contact first hypothesis states that fusion partners tend to colocaliz...

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Detalles Bibliográficos
Autores principales: Xing, Zhihao, Mai, Huirong, Liu, Xiaorong, Fu, Xiaoying, Zhang, Xingliang, Xie, Lichun, Chen, Yunsheng, Shlien, Adam, Wen, Feiqiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361544/
https://www.ncbi.nlm.nih.gov/pubmed/35945623
http://dx.doi.org/10.1186/s13059-022-02740-9

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