Cargando…

Comparing evolvement of visual field defect in neuromyelitis optica spectrum disorder-optic neuritis and idiopathic optic neuritis: a prospective study

PURPOSE: To compare the evolvement of visual field (VF) defect in neuromyelitis optica spectrum disorder-optic neuritis (NMOSD-ON) and idiopathic optic neuritis (IDON). METHODS: This prospective study involved 104 optic neuritis (ON) patients followed up for ≥ 6 months (33 patients with NMOSD-ON and...

Descripción completa

Detalles Bibliográficos
Autores principales: Liang, Jiaqi, Zhang, Yuxin, Liu, Kaiqun, Xu, Xiaoyu, Zhao, Xiujuan, Qiu, Wei, Zhang, Xinyu, Yang, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361552/
https://www.ncbi.nlm.nih.gov/pubmed/35945524
http://dx.doi.org/10.1186/s12886-022-02510-y
_version_ 1784764550595215360
author Liang, Jiaqi
Zhang, Yuxin
Liu, Kaiqun
Xu, Xiaoyu
Zhao, Xiujuan
Qiu, Wei
Zhang, Xinyu
Yang, Hui
author_facet Liang, Jiaqi
Zhang, Yuxin
Liu, Kaiqun
Xu, Xiaoyu
Zhao, Xiujuan
Qiu, Wei
Zhang, Xinyu
Yang, Hui
author_sort Liang, Jiaqi
collection PubMed
description PURPOSE: To compare the evolvement of visual field (VF) defect in neuromyelitis optica spectrum disorder-optic neuritis (NMOSD-ON) and idiopathic optic neuritis (IDON). METHODS: This prospective study involved 104 optic neuritis (ON) patients followed up for ≥ 6 months (33 patients with NMOSD-ON and 71 patients with IDON). The pattern and recovery pattern of VF defect, mean defect (MD) and pattern standard deviation (PSD) of VF, as well as BCVA at onset, 1 month (1 m), 3 months (3 m), and ≥ 6 months (6 m) after onset were compared between two groups. Analysis of these indicators in first episode patients was also done. RESULTS: Diffuse abnormalities and nerve fiber bundle abnormalities were the two most common patterns in both groups. The percentage of neurologic abnormality of VF defect in NMOSD-ON was higher than that of IDON. Compared with the IDON group, the MD and PSD of NMOSD-ON group were significantly worse at each follow-up. While a positive correlation in BCVA was found between 1 m and ≥ 6 m in the NMOSD-ON group only, a positive correlation was found between 1 m and ≥ 6 m in MD and PSD of both groups. A positive correlation was found between 3 m and ≥ 6 m in MD, PSD and BCVA of both groups. The quadrant recovery pattern was the most common pattern in both groups (57.1% in NMOSD-ON and 57.4% in IDON). The analysis of the first episode subgroup further confirmed the observation above. CONCLUSIONS: The NMOSD-ON patients tended to suffer more severe VF damage, VF irregularity and worse prognosis than that of IDON patients. Diffuse abnormalities and nerve fiber bundle abnormalities were the two most common types in both groups, while neurologic abnormality more common in NMOSD-ON and central scotoma more common in IDON. The visual functions of 1 m in NMOSD-ON and 3 m in IDON were related to its prognosis.
format Online
Article
Text
id pubmed-9361552
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-93615522022-08-10 Comparing evolvement of visual field defect in neuromyelitis optica spectrum disorder-optic neuritis and idiopathic optic neuritis: a prospective study Liang, Jiaqi Zhang, Yuxin Liu, Kaiqun Xu, Xiaoyu Zhao, Xiujuan Qiu, Wei Zhang, Xinyu Yang, Hui BMC Ophthalmol Research PURPOSE: To compare the evolvement of visual field (VF) defect in neuromyelitis optica spectrum disorder-optic neuritis (NMOSD-ON) and idiopathic optic neuritis (IDON). METHODS: This prospective study involved 104 optic neuritis (ON) patients followed up for ≥ 6 months (33 patients with NMOSD-ON and 71 patients with IDON). The pattern and recovery pattern of VF defect, mean defect (MD) and pattern standard deviation (PSD) of VF, as well as BCVA at onset, 1 month (1 m), 3 months (3 m), and ≥ 6 months (6 m) after onset were compared between two groups. Analysis of these indicators in first episode patients was also done. RESULTS: Diffuse abnormalities and nerve fiber bundle abnormalities were the two most common patterns in both groups. The percentage of neurologic abnormality of VF defect in NMOSD-ON was higher than that of IDON. Compared with the IDON group, the MD and PSD of NMOSD-ON group were significantly worse at each follow-up. While a positive correlation in BCVA was found between 1 m and ≥ 6 m in the NMOSD-ON group only, a positive correlation was found between 1 m and ≥ 6 m in MD and PSD of both groups. A positive correlation was found between 3 m and ≥ 6 m in MD, PSD and BCVA of both groups. The quadrant recovery pattern was the most common pattern in both groups (57.1% in NMOSD-ON and 57.4% in IDON). The analysis of the first episode subgroup further confirmed the observation above. CONCLUSIONS: The NMOSD-ON patients tended to suffer more severe VF damage, VF irregularity and worse prognosis than that of IDON patients. Diffuse abnormalities and nerve fiber bundle abnormalities were the two most common types in both groups, while neurologic abnormality more common in NMOSD-ON and central scotoma more common in IDON. The visual functions of 1 m in NMOSD-ON and 3 m in IDON were related to its prognosis. BioMed Central 2022-08-09 /pmc/articles/PMC9361552/ /pubmed/35945524 http://dx.doi.org/10.1186/s12886-022-02510-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Liang, Jiaqi
Zhang, Yuxin
Liu, Kaiqun
Xu, Xiaoyu
Zhao, Xiujuan
Qiu, Wei
Zhang, Xinyu
Yang, Hui
Comparing evolvement of visual field defect in neuromyelitis optica spectrum disorder-optic neuritis and idiopathic optic neuritis: a prospective study
title Comparing evolvement of visual field defect in neuromyelitis optica spectrum disorder-optic neuritis and idiopathic optic neuritis: a prospective study
title_full Comparing evolvement of visual field defect in neuromyelitis optica spectrum disorder-optic neuritis and idiopathic optic neuritis: a prospective study
title_fullStr Comparing evolvement of visual field defect in neuromyelitis optica spectrum disorder-optic neuritis and idiopathic optic neuritis: a prospective study
title_full_unstemmed Comparing evolvement of visual field defect in neuromyelitis optica spectrum disorder-optic neuritis and idiopathic optic neuritis: a prospective study
title_short Comparing evolvement of visual field defect in neuromyelitis optica spectrum disorder-optic neuritis and idiopathic optic neuritis: a prospective study
title_sort comparing evolvement of visual field defect in neuromyelitis optica spectrum disorder-optic neuritis and idiopathic optic neuritis: a prospective study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361552/
https://www.ncbi.nlm.nih.gov/pubmed/35945524
http://dx.doi.org/10.1186/s12886-022-02510-y
work_keys_str_mv AT liangjiaqi comparingevolvementofvisualfielddefectinneuromyelitisopticaspectrumdisorderopticneuritisandidiopathicopticneuritisaprospectivestudy
AT zhangyuxin comparingevolvementofvisualfielddefectinneuromyelitisopticaspectrumdisorderopticneuritisandidiopathicopticneuritisaprospectivestudy
AT liukaiqun comparingevolvementofvisualfielddefectinneuromyelitisopticaspectrumdisorderopticneuritisandidiopathicopticneuritisaprospectivestudy
AT xuxiaoyu comparingevolvementofvisualfielddefectinneuromyelitisopticaspectrumdisorderopticneuritisandidiopathicopticneuritisaprospectivestudy
AT zhaoxiujuan comparingevolvementofvisualfielddefectinneuromyelitisopticaspectrumdisorderopticneuritisandidiopathicopticneuritisaprospectivestudy
AT qiuwei comparingevolvementofvisualfielddefectinneuromyelitisopticaspectrumdisorderopticneuritisandidiopathicopticneuritisaprospectivestudy
AT zhangxinyu comparingevolvementofvisualfielddefectinneuromyelitisopticaspectrumdisorderopticneuritisandidiopathicopticneuritisaprospectivestudy
AT yanghui comparingevolvementofvisualfielddefectinneuromyelitisopticaspectrumdisorderopticneuritisandidiopathicopticneuritisaprospectivestudy