Conditional knockout of ASK1 in microglia/macrophages attenuates epileptic seizures and long-term neurobehavioural comorbidities by modulating the inflammatory responses of microglia/macrophages

BACKGROUND: Apoptosis signal-regulating kinase 1 (ASK1) not only causes neuronal programmed cell death via the mitochondrial pathway but also is an essential component of the signalling cascade during microglial activation. We hypothesize that ASK1 selective deletion modulates inflammatory responses...

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Detalles Bibliográficos
Autores principales: Zhang, Yiying, Wang, Zhangyang, Wang, Rongrong, Xia, Lu, Cai, Yiying, Tong, Fangchao, Gao, Yanqin, Ding, Jing, Wang, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361603/
https://www.ncbi.nlm.nih.gov/pubmed/35941644
http://dx.doi.org/10.1186/s12974-022-02560-5

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