Role of m6A writers, erasers and readers in cancer

The N(6)-methyladenosine (m6A) modification is the most pervasive modification of human RNAs. In recent years, an increasing number of studies have suggested that m6A likely plays important roles in cancers. Many studies have demonstrated that m6A is involved in the biological functions of cancer ce...

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Autores principales: Fang, Zhen, Mei, Wentong, Qu, Chang, Lu, Jiongdi, Shang, Liang, Cao, Feng, Li, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361621/
https://www.ncbi.nlm.nih.gov/pubmed/35945641
http://dx.doi.org/10.1186/s40164-022-00298-7
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author Fang, Zhen
Mei, Wentong
Qu, Chang
Lu, Jiongdi
Shang, Liang
Cao, Feng
Li, Fei
author_facet Fang, Zhen
Mei, Wentong
Qu, Chang
Lu, Jiongdi
Shang, Liang
Cao, Feng
Li, Fei
author_sort Fang, Zhen
collection PubMed
description The N(6)-methyladenosine (m6A) modification is the most pervasive modification of human RNAs. In recent years, an increasing number of studies have suggested that m6A likely plays important roles in cancers. Many studies have demonstrated that m6A is involved in the biological functions of cancer cells, such as proliferation, invasion, metastasis, and drug resistance. In addition, m6A is closely related to the prognosis of cancer patients. In this review, we highlight recent advances in understanding the function of m6A in various cancers. We emphasize the importance of m6A to cancer progression and look forward to describe future research directions. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40164-022-00298-7.
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spelling pubmed-93616212022-08-10 Role of m6A writers, erasers and readers in cancer Fang, Zhen Mei, Wentong Qu, Chang Lu, Jiongdi Shang, Liang Cao, Feng Li, Fei Exp Hematol Oncol Review The N(6)-methyladenosine (m6A) modification is the most pervasive modification of human RNAs. In recent years, an increasing number of studies have suggested that m6A likely plays important roles in cancers. Many studies have demonstrated that m6A is involved in the biological functions of cancer cells, such as proliferation, invasion, metastasis, and drug resistance. In addition, m6A is closely related to the prognosis of cancer patients. In this review, we highlight recent advances in understanding the function of m6A in various cancers. We emphasize the importance of m6A to cancer progression and look forward to describe future research directions. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40164-022-00298-7. BioMed Central 2022-08-09 /pmc/articles/PMC9361621/ /pubmed/35945641 http://dx.doi.org/10.1186/s40164-022-00298-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Fang, Zhen
Mei, Wentong
Qu, Chang
Lu, Jiongdi
Shang, Liang
Cao, Feng
Li, Fei
Role of m6A writers, erasers and readers in cancer
title Role of m6A writers, erasers and readers in cancer
title_full Role of m6A writers, erasers and readers in cancer
title_fullStr Role of m6A writers, erasers and readers in cancer
title_full_unstemmed Role of m6A writers, erasers and readers in cancer
title_short Role of m6A writers, erasers and readers in cancer
title_sort role of m6a writers, erasers and readers in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361621/
https://www.ncbi.nlm.nih.gov/pubmed/35945641
http://dx.doi.org/10.1186/s40164-022-00298-7
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