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Peripapillary structural and microvascular alterations in early dysthyroid optic neuropathy

BACKGROUND: To explore the changes in blood supply and structure around the optic nerve head (ONH) in thyroid-associated ophthalmopathy (TAO) patients with suspected dysthyroid optic neuropathy (DON). METHODS: TAO patients [19 with DON; 24 non-DON (NDON); 20 with equivocal DON (EDON)], and 34 contro...

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Autores principales: Wu, Yufei, Yang, Qiaoli, Ding, Liujun, Tu, Yunhai, Deng, Xiaoyu, Yang, Yan, Shen, Meixiao, Lu, Qinkang, Lu, Fan, Chen, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361673/
https://www.ncbi.nlm.nih.gov/pubmed/35941698
http://dx.doi.org/10.1186/s40662-022-00301-6
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author Wu, Yufei
Yang, Qiaoli
Ding, Liujun
Tu, Yunhai
Deng, Xiaoyu
Yang, Yan
Shen, Meixiao
Lu, Qinkang
Lu, Fan
Chen, Qi
author_facet Wu, Yufei
Yang, Qiaoli
Ding, Liujun
Tu, Yunhai
Deng, Xiaoyu
Yang, Yan
Shen, Meixiao
Lu, Qinkang
Lu, Fan
Chen, Qi
author_sort Wu, Yufei
collection PubMed
description BACKGROUND: To explore the changes in blood supply and structure around the optic nerve head (ONH) in thyroid-associated ophthalmopathy (TAO) patients with suspected dysthyroid optic neuropathy (DON). METHODS: TAO patients [19 with DON; 24 non-DON (NDON); 20 with equivocal DON (EDON)], and 34 control subjects were examined. Optical coherence tomography angiography (OCTA) was used to obtain peripapillary retinal nerve fiber layer (p-RNFL) and vessel density parameters, including the ONH whole image vessel density (ONH-wiVD) and the radial peripapillary capillary vessel density (RPC-VD) in early DON. RESULTS: Although there were no differences in p-RNFL thickness among the groups, there were differences in the ONH-wiVD of each grid section and the RPC-VD in all areas (P < 0.01). Compared with healthy controls, the EDON eyes had significantly lower RPC-VDs in all aeras (P < 0.05).The peripapillary region was further divided into eight sectors, and the RPC-VD in the temporal upper, superior temporal, and temporal lower sectors in the EDON group were significantly lower than in the controls. The visual impairment was closely related to the loss of peripapillary capillary vessel density. Univariate correlation analysis showed that the ONH-wiVD and RPC-VD of the TAO groups were negatively correlated with the intraocular pressure (r = − 0.296, P = 0.006; r = − 0.258, P = 0.016 respectively). CONCLUSIONS: EDON patients had significantly lower ONH-wiVD and RPC-VD than control subjects, and the temporal and upper VDs were more likely to be affected in the early stage of TAO. The combined use of spectral domain optical coherence tomography and OCTA technologies offer a new method for early diagnosis of suspected DON patients.
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spelling pubmed-93616732022-08-10 Peripapillary structural and microvascular alterations in early dysthyroid optic neuropathy Wu, Yufei Yang, Qiaoli Ding, Liujun Tu, Yunhai Deng, Xiaoyu Yang, Yan Shen, Meixiao Lu, Qinkang Lu, Fan Chen, Qi Eye Vis (Lond) Research BACKGROUND: To explore the changes in blood supply and structure around the optic nerve head (ONH) in thyroid-associated ophthalmopathy (TAO) patients with suspected dysthyroid optic neuropathy (DON). METHODS: TAO patients [19 with DON; 24 non-DON (NDON); 20 with equivocal DON (EDON)], and 34 control subjects were examined. Optical coherence tomography angiography (OCTA) was used to obtain peripapillary retinal nerve fiber layer (p-RNFL) and vessel density parameters, including the ONH whole image vessel density (ONH-wiVD) and the radial peripapillary capillary vessel density (RPC-VD) in early DON. RESULTS: Although there were no differences in p-RNFL thickness among the groups, there were differences in the ONH-wiVD of each grid section and the RPC-VD in all areas (P < 0.01). Compared with healthy controls, the EDON eyes had significantly lower RPC-VDs in all aeras (P < 0.05).The peripapillary region was further divided into eight sectors, and the RPC-VD in the temporal upper, superior temporal, and temporal lower sectors in the EDON group were significantly lower than in the controls. The visual impairment was closely related to the loss of peripapillary capillary vessel density. Univariate correlation analysis showed that the ONH-wiVD and RPC-VD of the TAO groups were negatively correlated with the intraocular pressure (r = − 0.296, P = 0.006; r = − 0.258, P = 0.016 respectively). CONCLUSIONS: EDON patients had significantly lower ONH-wiVD and RPC-VD than control subjects, and the temporal and upper VDs were more likely to be affected in the early stage of TAO. The combined use of spectral domain optical coherence tomography and OCTA technologies offer a new method for early diagnosis of suspected DON patients. BioMed Central 2022-08-09 /pmc/articles/PMC9361673/ /pubmed/35941698 http://dx.doi.org/10.1186/s40662-022-00301-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Wu, Yufei
Yang, Qiaoli
Ding, Liujun
Tu, Yunhai
Deng, Xiaoyu
Yang, Yan
Shen, Meixiao
Lu, Qinkang
Lu, Fan
Chen, Qi
Peripapillary structural and microvascular alterations in early dysthyroid optic neuropathy
title Peripapillary structural and microvascular alterations in early dysthyroid optic neuropathy
title_full Peripapillary structural and microvascular alterations in early dysthyroid optic neuropathy
title_fullStr Peripapillary structural and microvascular alterations in early dysthyroid optic neuropathy
title_full_unstemmed Peripapillary structural and microvascular alterations in early dysthyroid optic neuropathy
title_short Peripapillary structural and microvascular alterations in early dysthyroid optic neuropathy
title_sort peripapillary structural and microvascular alterations in early dysthyroid optic neuropathy
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361673/
https://www.ncbi.nlm.nih.gov/pubmed/35941698
http://dx.doi.org/10.1186/s40662-022-00301-6
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