Exercise and colorectal cancer: prevention and molecular mechanisms

Exercise and physical activity have been shown to be strongly associated with a decreased incidence rate of various chronic diseases especially numerous human malignancies. A huge number of clinical trials and meta-analysis have demonstrated that exercise is significantly effective in lowering the r...

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Autores principales: Amirsasan, Ramin, Akbarzadeh, Maryam, Akbarzadeh, Shabnam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361674/
https://www.ncbi.nlm.nih.gov/pubmed/35945569
http://dx.doi.org/10.1186/s12935-022-02670-3
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author Amirsasan, Ramin
Akbarzadeh, Maryam
Akbarzadeh, Shabnam
author_facet Amirsasan, Ramin
Akbarzadeh, Maryam
Akbarzadeh, Shabnam
author_sort Amirsasan, Ramin
collection PubMed
description Exercise and physical activity have been shown to be strongly associated with a decreased incidence rate of various chronic diseases especially numerous human malignancies. A huge number of clinical trials and meta-analysis have demonstrated that exercise is significantly effective in lowering the risk of colorectal cancer. In addition, it is suggested as an effective therapeutic modality against this cancer type. Therefore, in this review, we will review comprehensibly the effects of exercise in preventing, treating, and alleviating the adverse effects of conventional therapeutic options in colorectal cancer. Moreover, the possible mechanisms underlying the positive effects of exercise and physical activity in colorectal cancer, including regulation of inflammation, apoptosis, growth factor axis, immunity, epigenetic, etc. will be also discussed.
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spelling pubmed-93616742022-08-10 Exercise and colorectal cancer: prevention and molecular mechanisms Amirsasan, Ramin Akbarzadeh, Maryam Akbarzadeh, Shabnam Cancer Cell Int Review Exercise and physical activity have been shown to be strongly associated with a decreased incidence rate of various chronic diseases especially numerous human malignancies. A huge number of clinical trials and meta-analysis have demonstrated that exercise is significantly effective in lowering the risk of colorectal cancer. In addition, it is suggested as an effective therapeutic modality against this cancer type. Therefore, in this review, we will review comprehensibly the effects of exercise in preventing, treating, and alleviating the adverse effects of conventional therapeutic options in colorectal cancer. Moreover, the possible mechanisms underlying the positive effects of exercise and physical activity in colorectal cancer, including regulation of inflammation, apoptosis, growth factor axis, immunity, epigenetic, etc. will be also discussed. BioMed Central 2022-08-09 /pmc/articles/PMC9361674/ /pubmed/35945569 http://dx.doi.org/10.1186/s12935-022-02670-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Amirsasan, Ramin
Akbarzadeh, Maryam
Akbarzadeh, Shabnam
Exercise and colorectal cancer: prevention and molecular mechanisms
title Exercise and colorectal cancer: prevention and molecular mechanisms
title_full Exercise and colorectal cancer: prevention and molecular mechanisms
title_fullStr Exercise and colorectal cancer: prevention and molecular mechanisms
title_full_unstemmed Exercise and colorectal cancer: prevention and molecular mechanisms
title_short Exercise and colorectal cancer: prevention and molecular mechanisms
title_sort exercise and colorectal cancer: prevention and molecular mechanisms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361674/
https://www.ncbi.nlm.nih.gov/pubmed/35945569
http://dx.doi.org/10.1186/s12935-022-02670-3
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