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Simultaneous testicle and epididymis vasculitis revealing granulomatosis with polyangiitis

Granulomatosis with polyangiitis (GPA) is a systemic necrotizing granulomatous vasculitis, which predominantly affects small‐sized blood vessels. We aimed to report a case of GPA involving testicles and epididymis taken for malignancy. A 75‐year‐old patient was admitted for a painful left testicular...

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Autores principales: Kechida, Melek, Ktari, Kamel, Jellazi, Mohamed, Mesfar, Rym, Khochtali, Ines, Saad, Hammadi, Njim, Leila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361717/
https://www.ncbi.nlm.nih.gov/pubmed/35957766
http://dx.doi.org/10.1002/ccr3.6231
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author Kechida, Melek
Ktari, Kamel
Jellazi, Mohamed
Mesfar, Rym
Khochtali, Ines
Saad, Hammadi
Njim, Leila
author_facet Kechida, Melek
Ktari, Kamel
Jellazi, Mohamed
Mesfar, Rym
Khochtali, Ines
Saad, Hammadi
Njim, Leila
author_sort Kechida, Melek
collection PubMed
description Granulomatosis with polyangiitis (GPA) is a systemic necrotizing granulomatous vasculitis, which predominantly affects small‐sized blood vessels. We aimed to report a case of GPA involving testicles and epididymis taken for malignancy. A 75‐year‐old patient was admitted for a painful left testicular mass. There was no extra urogenital manifestations on examination and the workup was unremarkable. Histological findings after orchidectomy revealed granulomatous inflammation of the testis and epididymis with fibrinoid necrosis and necrotic vasculitis consisting with the diagnosis of GPA. Further investigations regarding ear, nose, throat, pulmonary, and renal involvement were negative. Proteinase 3 antineutrophil cytoplasmic antibodies (PR3‐ANCA) test was negative. Furthermore, infectious diseases especially tuberculosis were ruled out. Based on histopathological findings, limited GPA was diagnosed. The patient was treated with methotrexate and prednisone with good outcome. There was no relapse after 1 year of follow‐up. Isolated urogenital involvement may occur at the onset of GPA and can be taken for malignancy. Histopathological findings are the gold standard for the diagnosis. Treatment is based on steroids and immunosuppressive drugs.
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spelling pubmed-93617172022-08-10 Simultaneous testicle and epididymis vasculitis revealing granulomatosis with polyangiitis Kechida, Melek Ktari, Kamel Jellazi, Mohamed Mesfar, Rym Khochtali, Ines Saad, Hammadi Njim, Leila Clin Case Rep Case Report Granulomatosis with polyangiitis (GPA) is a systemic necrotizing granulomatous vasculitis, which predominantly affects small‐sized blood vessels. We aimed to report a case of GPA involving testicles and epididymis taken for malignancy. A 75‐year‐old patient was admitted for a painful left testicular mass. There was no extra urogenital manifestations on examination and the workup was unremarkable. Histological findings after orchidectomy revealed granulomatous inflammation of the testis and epididymis with fibrinoid necrosis and necrotic vasculitis consisting with the diagnosis of GPA. Further investigations regarding ear, nose, throat, pulmonary, and renal involvement were negative. Proteinase 3 antineutrophil cytoplasmic antibodies (PR3‐ANCA) test was negative. Furthermore, infectious diseases especially tuberculosis were ruled out. Based on histopathological findings, limited GPA was diagnosed. The patient was treated with methotrexate and prednisone with good outcome. There was no relapse after 1 year of follow‐up. Isolated urogenital involvement may occur at the onset of GPA and can be taken for malignancy. Histopathological findings are the gold standard for the diagnosis. Treatment is based on steroids and immunosuppressive drugs. John Wiley and Sons Inc. 2022-08-09 /pmc/articles/PMC9361717/ /pubmed/35957766 http://dx.doi.org/10.1002/ccr3.6231 Text en © 2022 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Report
Kechida, Melek
Ktari, Kamel
Jellazi, Mohamed
Mesfar, Rym
Khochtali, Ines
Saad, Hammadi
Njim, Leila
Simultaneous testicle and epididymis vasculitis revealing granulomatosis with polyangiitis
title Simultaneous testicle and epididymis vasculitis revealing granulomatosis with polyangiitis
title_full Simultaneous testicle and epididymis vasculitis revealing granulomatosis with polyangiitis
title_fullStr Simultaneous testicle and epididymis vasculitis revealing granulomatosis with polyangiitis
title_full_unstemmed Simultaneous testicle and epididymis vasculitis revealing granulomatosis with polyangiitis
title_short Simultaneous testicle and epididymis vasculitis revealing granulomatosis with polyangiitis
title_sort simultaneous testicle and epididymis vasculitis revealing granulomatosis with polyangiitis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361717/
https://www.ncbi.nlm.nih.gov/pubmed/35957766
http://dx.doi.org/10.1002/ccr3.6231
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