The Number of MRGPRX2-Expressing Cells Is Increased in Skin Lesions of Patients With Indolent Systemic Mastocytosis, But Is Not Linked to Symptom Severity

BACKGROUND: Recently, the expression of the mast cell (MC) receptor Mas-related G protein–coupled receptor X2 (MRGPRX2) has been detected in lesional skin of adult patients with cutaneous mastocytosis. As of yet, little is known about the clinical relevance of MRGPRX2 and its agonists in patients wi...

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Detalles Bibliográficos
Autores principales: Pyatilova, Polina, Ashry, Tameem, Luo, Yanyan, He, Jiajun, Bonnekoh, Hanna, Jiao, Qingqing, Moñino-Romero, Sherezade, Hu, Man, Scheffel, Jörg, Frischbutter, Stefan, Hermans, Maud A. W., Youngblood, Bradford A., Maurer, Marcus, Siebenhaar, Frank, Kolkhir, Pavel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361751/
https://www.ncbi.nlm.nih.gov/pubmed/35958589
http://dx.doi.org/10.3389/fimmu.2022.930945

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