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Feasibility of oral microbiome profiles associated with oral squamous cell carcinoma
OBJECTIVE: Recently, the possibility that oral microbiomes is associated with oral squamous cell carcinoma (OSCC) initiation and progression has attracted attention; however, this association is still unclear. Here, we comprehensively analyze the microbiome profiles of saliva samples using next-gene...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361761/ https://www.ncbi.nlm.nih.gov/pubmed/35958277 http://dx.doi.org/10.1080/20002297.2022.2105574 |
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author | Hashimoto, Kengo Shimizu, Dai Ueda, Sei Miyabe, Satoru Oh-Iwa, Ichiro Nagao, Toru Shimozato, Kazuo Nomoto, Shuji |
author_facet | Hashimoto, Kengo Shimizu, Dai Ueda, Sei Miyabe, Satoru Oh-Iwa, Ichiro Nagao, Toru Shimozato, Kazuo Nomoto, Shuji |
author_sort | Hashimoto, Kengo |
collection | PubMed |
description | OBJECTIVE: Recently, the possibility that oral microbiomes is associated with oral squamous cell carcinoma (OSCC) initiation and progression has attracted attention; however, this association is still unclear. Here, we comprehensively analyze the microbiome profiles of saliva samples using next-generation sequencing followed by determining the association between oral microbiome profiles and OSCC. MATERIALS AND METHODS: Microbiome profiles in saliva samples from patients with OSCC, oral leukoplakia (OLK), and postoperative OSCC (Post) were analyzed. Candidate OSCC-associated bacteria were identified by comparing the bacterial diversity and relative abundance of each group based on these microbiome profiles, and their applicability as OSCC detection tools were evaluated. RESULTS: There were significant differences in genus abundances (Streptococcus, Aggregatibacter, and Alloprevotella) among the groups from saliva samples. In the OSCC group, compared with the OLK and Post groups, abundances of the genus Fusobacterium, phylum Fusobacteria and phylum Bacteroidetes were markedly increased and that of the genus Streptococcus and phylum Firmicutes were decreased. CONCLUSION: The results suggested a strong association of these bacteria with OSCC. Especially, phylum Fusobacterium was significantly associated with early recurrence of OSCC. Thus, oral microbiome analysis may have a potential of novel OSCC detection and prognostic tool. |
format | Online Article Text |
id | pubmed-9361761 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-93617612022-08-10 Feasibility of oral microbiome profiles associated with oral squamous cell carcinoma Hashimoto, Kengo Shimizu, Dai Ueda, Sei Miyabe, Satoru Oh-Iwa, Ichiro Nagao, Toru Shimozato, Kazuo Nomoto, Shuji J Oral Microbiol Original Article OBJECTIVE: Recently, the possibility that oral microbiomes is associated with oral squamous cell carcinoma (OSCC) initiation and progression has attracted attention; however, this association is still unclear. Here, we comprehensively analyze the microbiome profiles of saliva samples using next-generation sequencing followed by determining the association between oral microbiome profiles and OSCC. MATERIALS AND METHODS: Microbiome profiles in saliva samples from patients with OSCC, oral leukoplakia (OLK), and postoperative OSCC (Post) were analyzed. Candidate OSCC-associated bacteria were identified by comparing the bacterial diversity and relative abundance of each group based on these microbiome profiles, and their applicability as OSCC detection tools were evaluated. RESULTS: There were significant differences in genus abundances (Streptococcus, Aggregatibacter, and Alloprevotella) among the groups from saliva samples. In the OSCC group, compared with the OLK and Post groups, abundances of the genus Fusobacterium, phylum Fusobacteria and phylum Bacteroidetes were markedly increased and that of the genus Streptococcus and phylum Firmicutes were decreased. CONCLUSION: The results suggested a strong association of these bacteria with OSCC. Especially, phylum Fusobacterium was significantly associated with early recurrence of OSCC. Thus, oral microbiome analysis may have a potential of novel OSCC detection and prognostic tool. Taylor & Francis 2022-08-07 /pmc/articles/PMC9361761/ /pubmed/35958277 http://dx.doi.org/10.1080/20002297.2022.2105574 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Hashimoto, Kengo Shimizu, Dai Ueda, Sei Miyabe, Satoru Oh-Iwa, Ichiro Nagao, Toru Shimozato, Kazuo Nomoto, Shuji Feasibility of oral microbiome profiles associated with oral squamous cell carcinoma |
title | Feasibility of oral microbiome profiles associated with oral squamous cell carcinoma |
title_full | Feasibility of oral microbiome profiles associated with oral squamous cell carcinoma |
title_fullStr | Feasibility of oral microbiome profiles associated with oral squamous cell carcinoma |
title_full_unstemmed | Feasibility of oral microbiome profiles associated with oral squamous cell carcinoma |
title_short | Feasibility of oral microbiome profiles associated with oral squamous cell carcinoma |
title_sort | feasibility of oral microbiome profiles associated with oral squamous cell carcinoma |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361761/ https://www.ncbi.nlm.nih.gov/pubmed/35958277 http://dx.doi.org/10.1080/20002297.2022.2105574 |
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