Gasdermin D-dependent platelet pyroptosis exacerbates NET formation and inflammation in severe sepsis

Platelets have emerged as key inflammatory cells implicated in the pathology of sepsis, but their contributions to rapid clinical deterioration and dysregulated inflammation have not been defined. Here, we show that the incidence of thrombocytopathy and inflammatory cytokine release was significantl...

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Detalles Bibliográficos
Autores principales: Su, Meiling, Chen, Chaofei, Li, Shaoying, Li, Musheng, Zeng, Zhi, Zhang, Yuan, Xia, Luoxing, Li, Xiuzhen, Zheng, Dezhong, Lin, Qiqi, Fan, Xuejiao, Wen, Ying, Liu, Yingying, Chen, Feiyan, Luo, Wei, Bu, Yun, Qin, Jinhong, Guo, Manli, Qiu, Miaoyun, Sun, Lei, Liu, Renjing, Wang, Ping, Hwa, John, Tang, Wai Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9362711/
https://www.ncbi.nlm.nih.gov/pubmed/35967457
http://dx.doi.org/10.1038/s44161-022-00108-7

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