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Vitamin K Status and Cognitive Function in Adults with Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort

Vitamin K is linked to cognitive function, but studies in individuals with chronic kidney disease (CKD), who are at risk for vitamin K insufficiency and cognitive impairment, are lacking. The cross-sectional association of vitamin K status biomarkers with cognitive performance was evaluated in ≥55-y...

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Autores principales: Shea, M Kyla, Wang, Jifan, Barger, Kathryn, Weiner, Daniel E, Booth, Sarah L, Seliger, Stephen L, Anderson, Amanda H, Deo, Rajat, Feldman, Harold I, Go, Alan S, He, Jiang, Ricardo, Ana C, Tamura, Manjula Kurella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9362761/
https://www.ncbi.nlm.nih.gov/pubmed/35957738
http://dx.doi.org/10.1093/cdn/nzac111
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author Shea, M Kyla
Wang, Jifan
Barger, Kathryn
Weiner, Daniel E
Booth, Sarah L
Seliger, Stephen L
Anderson, Amanda H
Deo, Rajat
Feldman, Harold I
Go, Alan S
He, Jiang
Ricardo, Ana C
Tamura, Manjula Kurella
author_facet Shea, M Kyla
Wang, Jifan
Barger, Kathryn
Weiner, Daniel E
Booth, Sarah L
Seliger, Stephen L
Anderson, Amanda H
Deo, Rajat
Feldman, Harold I
Go, Alan S
He, Jiang
Ricardo, Ana C
Tamura, Manjula Kurella
author_sort Shea, M Kyla
collection PubMed
description Vitamin K is linked to cognitive function, but studies in individuals with chronic kidney disease (CKD), who are at risk for vitamin K insufficiency and cognitive impairment, are lacking. The cross-sectional association of vitamin K status biomarkers with cognitive performance was evaluated in ≥55-y-old adults with CKD (N = 714, 49% female, 44% black). A composite score of a cognitive performance test battery, calculated by averaging the z scores of the individual tests, was the primary outcome. Vitamin K status was measured using plasma phylloquinone and dephospho-uncarboxylated matrix Gla protein [(dp)ucMGP]. Participants with low plasma (dp)ucMGP, reflecting higher vitamin K status, had better cognitive performance than those in the two higher (dp)ucMGP categories based on the composite outcome (P = 0.03), whereas it did not significantly differ according to plasma phylloquinone categories (P = 0.08). Neither biomarker was significantly associated with performance on individual tests (all P > 0.05). The importance of vitamin K to cognitive performance in adults with CKD remains to be clarified.
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spelling pubmed-93627612022-08-10 Vitamin K Status and Cognitive Function in Adults with Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort Shea, M Kyla Wang, Jifan Barger, Kathryn Weiner, Daniel E Booth, Sarah L Seliger, Stephen L Anderson, Amanda H Deo, Rajat Feldman, Harold I Go, Alan S He, Jiang Ricardo, Ana C Tamura, Manjula Kurella Curr Dev Nutr Brief Communication: Research Report Vitamin K is linked to cognitive function, but studies in individuals with chronic kidney disease (CKD), who are at risk for vitamin K insufficiency and cognitive impairment, are lacking. The cross-sectional association of vitamin K status biomarkers with cognitive performance was evaluated in ≥55-y-old adults with CKD (N = 714, 49% female, 44% black). A composite score of a cognitive performance test battery, calculated by averaging the z scores of the individual tests, was the primary outcome. Vitamin K status was measured using plasma phylloquinone and dephospho-uncarboxylated matrix Gla protein [(dp)ucMGP]. Participants with low plasma (dp)ucMGP, reflecting higher vitamin K status, had better cognitive performance than those in the two higher (dp)ucMGP categories based on the composite outcome (P = 0.03), whereas it did not significantly differ according to plasma phylloquinone categories (P = 0.08). Neither biomarker was significantly associated with performance on individual tests (all P > 0.05). The importance of vitamin K to cognitive performance in adults with CKD remains to be clarified. Oxford University Press 2022-06-24 /pmc/articles/PMC9362761/ /pubmed/35957738 http://dx.doi.org/10.1093/cdn/nzac111 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the American Society for Nutrition. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Communication: Research Report
Shea, M Kyla
Wang, Jifan
Barger, Kathryn
Weiner, Daniel E
Booth, Sarah L
Seliger, Stephen L
Anderson, Amanda H
Deo, Rajat
Feldman, Harold I
Go, Alan S
He, Jiang
Ricardo, Ana C
Tamura, Manjula Kurella
Vitamin K Status and Cognitive Function in Adults with Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort
title Vitamin K Status and Cognitive Function in Adults with Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort
title_full Vitamin K Status and Cognitive Function in Adults with Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort
title_fullStr Vitamin K Status and Cognitive Function in Adults with Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort
title_full_unstemmed Vitamin K Status and Cognitive Function in Adults with Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort
title_short Vitamin K Status and Cognitive Function in Adults with Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort
title_sort vitamin k status and cognitive function in adults with chronic kidney disease: the chronic renal insufficiency cohort
topic Brief Communication: Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9362761/
https://www.ncbi.nlm.nih.gov/pubmed/35957738
http://dx.doi.org/10.1093/cdn/nzac111
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