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Vitamin K Status and Cognitive Function in Adults with Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort
Vitamin K is linked to cognitive function, but studies in individuals with chronic kidney disease (CKD), who are at risk for vitamin K insufficiency and cognitive impairment, are lacking. The cross-sectional association of vitamin K status biomarkers with cognitive performance was evaluated in ≥55-y...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9362761/ https://www.ncbi.nlm.nih.gov/pubmed/35957738 http://dx.doi.org/10.1093/cdn/nzac111 |
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author | Shea, M Kyla Wang, Jifan Barger, Kathryn Weiner, Daniel E Booth, Sarah L Seliger, Stephen L Anderson, Amanda H Deo, Rajat Feldman, Harold I Go, Alan S He, Jiang Ricardo, Ana C Tamura, Manjula Kurella |
author_facet | Shea, M Kyla Wang, Jifan Barger, Kathryn Weiner, Daniel E Booth, Sarah L Seliger, Stephen L Anderson, Amanda H Deo, Rajat Feldman, Harold I Go, Alan S He, Jiang Ricardo, Ana C Tamura, Manjula Kurella |
author_sort | Shea, M Kyla |
collection | PubMed |
description | Vitamin K is linked to cognitive function, but studies in individuals with chronic kidney disease (CKD), who are at risk for vitamin K insufficiency and cognitive impairment, are lacking. The cross-sectional association of vitamin K status biomarkers with cognitive performance was evaluated in ≥55-y-old adults with CKD (N = 714, 49% female, 44% black). A composite score of a cognitive performance test battery, calculated by averaging the z scores of the individual tests, was the primary outcome. Vitamin K status was measured using plasma phylloquinone and dephospho-uncarboxylated matrix Gla protein [(dp)ucMGP]. Participants with low plasma (dp)ucMGP, reflecting higher vitamin K status, had better cognitive performance than those in the two higher (dp)ucMGP categories based on the composite outcome (P = 0.03), whereas it did not significantly differ according to plasma phylloquinone categories (P = 0.08). Neither biomarker was significantly associated with performance on individual tests (all P > 0.05). The importance of vitamin K to cognitive performance in adults with CKD remains to be clarified. |
format | Online Article Text |
id | pubmed-9362761 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-93627612022-08-10 Vitamin K Status and Cognitive Function in Adults with Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort Shea, M Kyla Wang, Jifan Barger, Kathryn Weiner, Daniel E Booth, Sarah L Seliger, Stephen L Anderson, Amanda H Deo, Rajat Feldman, Harold I Go, Alan S He, Jiang Ricardo, Ana C Tamura, Manjula Kurella Curr Dev Nutr Brief Communication: Research Report Vitamin K is linked to cognitive function, but studies in individuals with chronic kidney disease (CKD), who are at risk for vitamin K insufficiency and cognitive impairment, are lacking. The cross-sectional association of vitamin K status biomarkers with cognitive performance was evaluated in ≥55-y-old adults with CKD (N = 714, 49% female, 44% black). A composite score of a cognitive performance test battery, calculated by averaging the z scores of the individual tests, was the primary outcome. Vitamin K status was measured using plasma phylloquinone and dephospho-uncarboxylated matrix Gla protein [(dp)ucMGP]. Participants with low plasma (dp)ucMGP, reflecting higher vitamin K status, had better cognitive performance than those in the two higher (dp)ucMGP categories based on the composite outcome (P = 0.03), whereas it did not significantly differ according to plasma phylloquinone categories (P = 0.08). Neither biomarker was significantly associated with performance on individual tests (all P > 0.05). The importance of vitamin K to cognitive performance in adults with CKD remains to be clarified. Oxford University Press 2022-06-24 /pmc/articles/PMC9362761/ /pubmed/35957738 http://dx.doi.org/10.1093/cdn/nzac111 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the American Society for Nutrition. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Brief Communication: Research Report Shea, M Kyla Wang, Jifan Barger, Kathryn Weiner, Daniel E Booth, Sarah L Seliger, Stephen L Anderson, Amanda H Deo, Rajat Feldman, Harold I Go, Alan S He, Jiang Ricardo, Ana C Tamura, Manjula Kurella Vitamin K Status and Cognitive Function in Adults with Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort |
title | Vitamin K Status and Cognitive Function in Adults with Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort |
title_full | Vitamin K Status and Cognitive Function in Adults with Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort |
title_fullStr | Vitamin K Status and Cognitive Function in Adults with Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort |
title_full_unstemmed | Vitamin K Status and Cognitive Function in Adults with Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort |
title_short | Vitamin K Status and Cognitive Function in Adults with Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort |
title_sort | vitamin k status and cognitive function in adults with chronic kidney disease: the chronic renal insufficiency cohort |
topic | Brief Communication: Research Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9362761/ https://www.ncbi.nlm.nih.gov/pubmed/35957738 http://dx.doi.org/10.1093/cdn/nzac111 |
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