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Stem Cell Therapy and Innate Lymphoid Cells

Innate lymphoid cells have the capability to communicate with other immune cell types to coordinate the immune system functioning during homeostasis and inflammation. However, these cells behave differently at the functional level, unlike T cells, these cells do not need antigen receptors for activa...

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Detalles Bibliográficos
Autores principales: Verma, Divya, Verma, Mukesh, Mishra, Rangnath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363162/
https://www.ncbi.nlm.nih.gov/pubmed/35958032
http://dx.doi.org/10.1155/2022/3530520
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author Verma, Divya
Verma, Mukesh
Mishra, Rangnath
author_facet Verma, Divya
Verma, Mukesh
Mishra, Rangnath
author_sort Verma, Divya
collection PubMed
description Innate lymphoid cells have the capability to communicate with other immune cell types to coordinate the immune system functioning during homeostasis and inflammation. However, these cells behave differently at the functional level, unlike T cells, these cells do not need antigen receptors for activation because they are activated by the interaction of their receptor ligation. In hematopoietic stem cell transplantation (HSCT), T cells and NK cells have been extensively studied but very few studies are available on ILCs. In this review, an attempt has been made to provide current information related to NK and ILCs cell-based stem cell therapies and role of the stem cells in the regulation of ILCs as well. Also, the latest information on the differentiation of NK cells and ILCs from CD34+ hematopoietic stem cells is covered in the article.
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spelling pubmed-93631622022-08-10 Stem Cell Therapy and Innate Lymphoid Cells Verma, Divya Verma, Mukesh Mishra, Rangnath Stem Cells Int Review Article Innate lymphoid cells have the capability to communicate with other immune cell types to coordinate the immune system functioning during homeostasis and inflammation. However, these cells behave differently at the functional level, unlike T cells, these cells do not need antigen receptors for activation because they are activated by the interaction of their receptor ligation. In hematopoietic stem cell transplantation (HSCT), T cells and NK cells have been extensively studied but very few studies are available on ILCs. In this review, an attempt has been made to provide current information related to NK and ILCs cell-based stem cell therapies and role of the stem cells in the regulation of ILCs as well. Also, the latest information on the differentiation of NK cells and ILCs from CD34+ hematopoietic stem cells is covered in the article. Hindawi 2022-08-02 /pmc/articles/PMC9363162/ /pubmed/35958032 http://dx.doi.org/10.1155/2022/3530520 Text en Copyright © 2022 Divya Verma et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Verma, Divya
Verma, Mukesh
Mishra, Rangnath
Stem Cell Therapy and Innate Lymphoid Cells
title Stem Cell Therapy and Innate Lymphoid Cells
title_full Stem Cell Therapy and Innate Lymphoid Cells
title_fullStr Stem Cell Therapy and Innate Lymphoid Cells
title_full_unstemmed Stem Cell Therapy and Innate Lymphoid Cells
title_short Stem Cell Therapy and Innate Lymphoid Cells
title_sort stem cell therapy and innate lymphoid cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363162/
https://www.ncbi.nlm.nih.gov/pubmed/35958032
http://dx.doi.org/10.1155/2022/3530520
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