The clinically relevant CYP2C8*3 and CYP2C9*2 haplotype is inherited from Neandertals

Genetic variation in genes encoding cytochrome P450 enzymes influences the metabolism of drugs and endogenous compounds. The locus containing the cytochrome genes CYP2C8 and CYP2C9 on chromosome 10 exhibits linkage disequilibrium between the CYP2C8*3 and CYP2C9*2 alleles, forming a haplotype of ~300...

Descripción completa

Detalles Bibliográficos
Autores principales: Haeggström, Sigrid, Ingelman-Sundberg, Magnus, Pääbo, Svante, Zeberg, Hugo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363273/
https://www.ncbi.nlm.nih.gov/pubmed/35780191
http://dx.doi.org/10.1038/s41397-022-00284-6
_version_ 1784764894392877056
author Haeggström, Sigrid
Ingelman-Sundberg, Magnus
Pääbo, Svante
Zeberg, Hugo
author_facet Haeggström, Sigrid
Ingelman-Sundberg, Magnus
Pääbo, Svante
Zeberg, Hugo
author_sort Haeggström, Sigrid
collection PubMed
description Genetic variation in genes encoding cytochrome P450 enzymes influences the metabolism of drugs and endogenous compounds. The locus containing the cytochrome genes CYP2C8 and CYP2C9 on chromosome 10 exhibits linkage disequilibrium between the CYP2C8*3 and CYP2C9*2 alleles, forming a haplotype of ~300 kilobases. This haplotype is associated with altered metabolism of several drugs, most notably reduced metabolism of warfarin and phenytoin, leading to toxicity at otherwise therapeutic doses. Here we show that this haplotype is inherited from Neandertals.
format Online
Article
Text
id pubmed-9363273
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-93632732022-08-11 The clinically relevant CYP2C8*3 and CYP2C9*2 haplotype is inherited from Neandertals Haeggström, Sigrid Ingelman-Sundberg, Magnus Pääbo, Svante Zeberg, Hugo Pharmacogenomics J Article Genetic variation in genes encoding cytochrome P450 enzymes influences the metabolism of drugs and endogenous compounds. The locus containing the cytochrome genes CYP2C8 and CYP2C9 on chromosome 10 exhibits linkage disequilibrium between the CYP2C8*3 and CYP2C9*2 alleles, forming a haplotype of ~300 kilobases. This haplotype is associated with altered metabolism of several drugs, most notably reduced metabolism of warfarin and phenytoin, leading to toxicity at otherwise therapeutic doses. Here we show that this haplotype is inherited from Neandertals. Nature Publishing Group UK 2022-07-02 2022 /pmc/articles/PMC9363273/ /pubmed/35780191 http://dx.doi.org/10.1038/s41397-022-00284-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Haeggström, Sigrid
Ingelman-Sundberg, Magnus
Pääbo, Svante
Zeberg, Hugo
The clinically relevant CYP2C8*3 and CYP2C9*2 haplotype is inherited from Neandertals
title The clinically relevant CYP2C8*3 and CYP2C9*2 haplotype is inherited from Neandertals
title_full The clinically relevant CYP2C8*3 and CYP2C9*2 haplotype is inherited from Neandertals
title_fullStr The clinically relevant CYP2C8*3 and CYP2C9*2 haplotype is inherited from Neandertals
title_full_unstemmed The clinically relevant CYP2C8*3 and CYP2C9*2 haplotype is inherited from Neandertals
title_short The clinically relevant CYP2C8*3 and CYP2C9*2 haplotype is inherited from Neandertals
title_sort clinically relevant cyp2c8*3 and cyp2c9*2 haplotype is inherited from neandertals
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363273/
https://www.ncbi.nlm.nih.gov/pubmed/35780191
http://dx.doi.org/10.1038/s41397-022-00284-6
work_keys_str_mv AT haeggstromsigrid theclinicallyrelevantcyp2c83andcyp2c92haplotypeisinheritedfromneandertals
AT ingelmansundbergmagnus theclinicallyrelevantcyp2c83andcyp2c92haplotypeisinheritedfromneandertals
AT paabosvante theclinicallyrelevantcyp2c83andcyp2c92haplotypeisinheritedfromneandertals
AT zeberghugo theclinicallyrelevantcyp2c83andcyp2c92haplotypeisinheritedfromneandertals
AT haeggstromsigrid clinicallyrelevantcyp2c83andcyp2c92haplotypeisinheritedfromneandertals
AT ingelmansundbergmagnus clinicallyrelevantcyp2c83andcyp2c92haplotypeisinheritedfromneandertals
AT paabosvante clinicallyrelevantcyp2c83andcyp2c92haplotypeisinheritedfromneandertals
AT zeberghugo clinicallyrelevantcyp2c83andcyp2c92haplotypeisinheritedfromneandertals

Ejemplares similares