The clinically relevant CYP2C8*3 and CYP2C9*2 haplotype is inherited from Neandertals

Genetic variation in genes encoding cytochrome P450 enzymes influences the metabolism of drugs and endogenous compounds. The locus containing the cytochrome genes CYP2C8 and CYP2C9 on chromosome 10 exhibits linkage disequilibrium between the CYP2C8*3 and CYP2C9*2 alleles, forming a haplotype of ~300...

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Detalles Bibliográficos
Autores principales: Haeggström, Sigrid, Ingelman-Sundberg, Magnus, Pääbo, Svante, Zeberg, Hugo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363273/
https://www.ncbi.nlm.nih.gov/pubmed/35780191
http://dx.doi.org/10.1038/s41397-022-00284-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363273/
https://www.ncbi.nlm.nih.gov/pubmed/35780191
http://dx.doi.org/10.1038/s41397-022-00284-6

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