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Associations of erythrocyte polyunsaturated fatty acids with incidence of stroke and stroke types in adult Chinese: a prospective study of over 8000 individuals

PURPOSE: There is limited and inconsistent evidence about the relationships of erythrocyte polyunsaturated fatty acids (PUFAs) with stroke and stroke types, particularly in China where the stroke rates are high. We aimed to investigate the associations of different erythrocyte PUFAs with incidence o...

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Autores principales: Sun, Liang, Du, Huaidong, Zong, Geng, Guo, Yu, Chen, Yan, Chen, Yiping, Yin, Huiyong, Pei, Pei, Yang, Ling, Chu, Qianqian, Yu, Canqing, Li, Yixue, Lv, Jun, Zheng, He, Zhou, Puchen, Chen, Junshi, Li, Liming, Chen, Zhengming, Lin, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363313/
https://www.ncbi.nlm.nih.gov/pubmed/35445833
http://dx.doi.org/10.1007/s00394-022-02879-y
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author Sun, Liang
Du, Huaidong
Zong, Geng
Guo, Yu
Chen, Yan
Chen, Yiping
Yin, Huiyong
Pei, Pei
Yang, Ling
Chu, Qianqian
Yu, Canqing
Li, Yixue
Lv, Jun
Zheng, He
Zhou, Puchen
Chen, Junshi
Li, Liming
Chen, Zhengming
Lin, Xu
author_facet Sun, Liang
Du, Huaidong
Zong, Geng
Guo, Yu
Chen, Yan
Chen, Yiping
Yin, Huiyong
Pei, Pei
Yang, Ling
Chu, Qianqian
Yu, Canqing
Li, Yixue
Lv, Jun
Zheng, He
Zhou, Puchen
Chen, Junshi
Li, Liming
Chen, Zhengming
Lin, Xu
author_sort Sun, Liang
collection PubMed
description PURPOSE: There is limited and inconsistent evidence about the relationships of erythrocyte polyunsaturated fatty acids (PUFAs) with stroke and stroke types, particularly in China where the stroke rates are high. We aimed to investigate the associations of different erythrocyte PUFAs with incidence of total stroke, ischemic stroke (IS), and intracerebral hemorrhage (ICH) in Chinese adults. METHODS: In the prospective China Kadoorie Biobank, erythrocyte PUFAs were measured using gas chromatography in 10,563 participants who attended 2013–14 resurvey. After a mean follow-up of 3.8 years, 412 incident stroke cases (342 IS, 53 ICH) were recorded among 8,159 participants without prior vascular diseases or diabetes. Cox regression yielded adjusted hazard ratios (HRs) for stroke associated with 13 PUFAs. RESULTS: Overall, the mean body mass index was 24.0 (3.4) kg/m(2) and the mean age was 58.1 (9.9) years. In multivariable analyses, 18:2n–6 was positively associated with ICH (HR = 2.33 [95% CIs 1.41, 3.82] for top versus bottom quintile, P(trend) = 0.007), but inversely associated with IS (0.69 [0.53,0.90], P(trend) = 0.027), while 20:3n-6 was positively associated with risk of IS (1.64 [1.32,2.04], P(trend) < 0.001), but not with ICH. Inverted-U shape curve associations were observed of 20:5n–3 with IS (P(nonlinear) = 0.002) and total stroke (P(nonlinear) = 0.008), with a threshold at 0.70%. After further adjustment for conventional CVD risk factors and dietary factors, these associations remained similar. CONCLUSION: Among relatively lean Chinese adults, erythrocyte PUFAs 18:2n–6, 20:3n–6 and 20:5n–3 showed different associations with risks of IS and ICH. These results would improve the understanding of stroke etiology. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00394-022-02879-y.
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spelling pubmed-93633132022-08-11 Associations of erythrocyte polyunsaturated fatty acids with incidence of stroke and stroke types in adult Chinese: a prospective study of over 8000 individuals Sun, Liang Du, Huaidong Zong, Geng Guo, Yu Chen, Yan Chen, Yiping Yin, Huiyong Pei, Pei Yang, Ling Chu, Qianqian Yu, Canqing Li, Yixue Lv, Jun Zheng, He Zhou, Puchen Chen, Junshi Li, Liming Chen, Zhengming Lin, Xu Eur J Nutr Original Contribution PURPOSE: There is limited and inconsistent evidence about the relationships of erythrocyte polyunsaturated fatty acids (PUFAs) with stroke and stroke types, particularly in China where the stroke rates are high. We aimed to investigate the associations of different erythrocyte PUFAs with incidence of total stroke, ischemic stroke (IS), and intracerebral hemorrhage (ICH) in Chinese adults. METHODS: In the prospective China Kadoorie Biobank, erythrocyte PUFAs were measured using gas chromatography in 10,563 participants who attended 2013–14 resurvey. After a mean follow-up of 3.8 years, 412 incident stroke cases (342 IS, 53 ICH) were recorded among 8,159 participants without prior vascular diseases or diabetes. Cox regression yielded adjusted hazard ratios (HRs) for stroke associated with 13 PUFAs. RESULTS: Overall, the mean body mass index was 24.0 (3.4) kg/m(2) and the mean age was 58.1 (9.9) years. In multivariable analyses, 18:2n–6 was positively associated with ICH (HR = 2.33 [95% CIs 1.41, 3.82] for top versus bottom quintile, P(trend) = 0.007), but inversely associated with IS (0.69 [0.53,0.90], P(trend) = 0.027), while 20:3n-6 was positively associated with risk of IS (1.64 [1.32,2.04], P(trend) < 0.001), but not with ICH. Inverted-U shape curve associations were observed of 20:5n–3 with IS (P(nonlinear) = 0.002) and total stroke (P(nonlinear) = 0.008), with a threshold at 0.70%. After further adjustment for conventional CVD risk factors and dietary factors, these associations remained similar. CONCLUSION: Among relatively lean Chinese adults, erythrocyte PUFAs 18:2n–6, 20:3n–6 and 20:5n–3 showed different associations with risks of IS and ICH. These results would improve the understanding of stroke etiology. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00394-022-02879-y. Springer Berlin Heidelberg 2022-04-21 2022 /pmc/articles/PMC9363313/ /pubmed/35445833 http://dx.doi.org/10.1007/s00394-022-02879-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visithttp://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Contribution
Sun, Liang
Du, Huaidong
Zong, Geng
Guo, Yu
Chen, Yan
Chen, Yiping
Yin, Huiyong
Pei, Pei
Yang, Ling
Chu, Qianqian
Yu, Canqing
Li, Yixue
Lv, Jun
Zheng, He
Zhou, Puchen
Chen, Junshi
Li, Liming
Chen, Zhengming
Lin, Xu
Associations of erythrocyte polyunsaturated fatty acids with incidence of stroke and stroke types in adult Chinese: a prospective study of over 8000 individuals
title Associations of erythrocyte polyunsaturated fatty acids with incidence of stroke and stroke types in adult Chinese: a prospective study of over 8000 individuals
title_full Associations of erythrocyte polyunsaturated fatty acids with incidence of stroke and stroke types in adult Chinese: a prospective study of over 8000 individuals
title_fullStr Associations of erythrocyte polyunsaturated fatty acids with incidence of stroke and stroke types in adult Chinese: a prospective study of over 8000 individuals
title_full_unstemmed Associations of erythrocyte polyunsaturated fatty acids with incidence of stroke and stroke types in adult Chinese: a prospective study of over 8000 individuals
title_short Associations of erythrocyte polyunsaturated fatty acids with incidence of stroke and stroke types in adult Chinese: a prospective study of over 8000 individuals
title_sort associations of erythrocyte polyunsaturated fatty acids with incidence of stroke and stroke types in adult chinese: a prospective study of over 8000 individuals
topic Original Contribution
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363313/
https://www.ncbi.nlm.nih.gov/pubmed/35445833
http://dx.doi.org/10.1007/s00394-022-02879-y
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