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Effect of Collateral Flow on Catheter-Based Assessment of Cardiac Microvascular Obstruction
Cardiac microvascular obstruction (MVO) associated with acute myocardial infarction (heart attack) is characterized by partial or complete elimination of perfusion in the myocardial microcirculation. A new catheter-based method (CoFI, Controlled Flow Infusion) has recently been developed to diagnose...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363345/ https://www.ncbi.nlm.nih.gov/pubmed/35639221 http://dx.doi.org/10.1007/s10439-022-02985-2 |
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author | Thirugnanasambandam, Mirunalini Frey, Sabrina Rösch, Yannick Mantegazza, Alberto Clavica, Francesco Schwartz, Robert S. Cesarovic, Nikola Obrist, Dominik |
author_facet | Thirugnanasambandam, Mirunalini Frey, Sabrina Rösch, Yannick Mantegazza, Alberto Clavica, Francesco Schwartz, Robert S. Cesarovic, Nikola Obrist, Dominik |
author_sort | Thirugnanasambandam, Mirunalini |
collection | PubMed |
description | Cardiac microvascular obstruction (MVO) associated with acute myocardial infarction (heart attack) is characterized by partial or complete elimination of perfusion in the myocardial microcirculation. A new catheter-based method (CoFI, Controlled Flow Infusion) has recently been developed to diagnose MVO in the catheterization laboratory during acute therapy of the heart attack. A porcine MVO model demonstrates that CoFI can accurately identify the increased hydraulic resistance of the affected microvascular bed. A benchtop microcirculation model was developed and tuned to reproduce in vivo MVO characteristics. The tuned benchtop model was then used to systematically study the effect of different levels of collateral flow. These experiments showed that measurements obtained in the catheter-based method were adversely affected such that collateral flow may be misinterpreted as MVO. Based on further analysis of the measured data, concepts to mitigate the adverse effects were formulated which allow discrimination between collateral flow and MVO. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10439-022-02985-2. |
format | Online Article Text |
id | pubmed-9363345 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-93633452022-08-11 Effect of Collateral Flow on Catheter-Based Assessment of Cardiac Microvascular Obstruction Thirugnanasambandam, Mirunalini Frey, Sabrina Rösch, Yannick Mantegazza, Alberto Clavica, Francesco Schwartz, Robert S. Cesarovic, Nikola Obrist, Dominik Ann Biomed Eng Original Article Cardiac microvascular obstruction (MVO) associated with acute myocardial infarction (heart attack) is characterized by partial or complete elimination of perfusion in the myocardial microcirculation. A new catheter-based method (CoFI, Controlled Flow Infusion) has recently been developed to diagnose MVO in the catheterization laboratory during acute therapy of the heart attack. A porcine MVO model demonstrates that CoFI can accurately identify the increased hydraulic resistance of the affected microvascular bed. A benchtop microcirculation model was developed and tuned to reproduce in vivo MVO characteristics. The tuned benchtop model was then used to systematically study the effect of different levels of collateral flow. These experiments showed that measurements obtained in the catheter-based method were adversely affected such that collateral flow may be misinterpreted as MVO. Based on further analysis of the measured data, concepts to mitigate the adverse effects were formulated which allow discrimination between collateral flow and MVO. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10439-022-02985-2. Springer International Publishing 2022-05-31 2022 /pmc/articles/PMC9363345/ /pubmed/35639221 http://dx.doi.org/10.1007/s10439-022-02985-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Thirugnanasambandam, Mirunalini Frey, Sabrina Rösch, Yannick Mantegazza, Alberto Clavica, Francesco Schwartz, Robert S. Cesarovic, Nikola Obrist, Dominik Effect of Collateral Flow on Catheter-Based Assessment of Cardiac Microvascular Obstruction |
title | Effect of Collateral Flow on Catheter-Based Assessment of Cardiac Microvascular Obstruction |
title_full | Effect of Collateral Flow on Catheter-Based Assessment of Cardiac Microvascular Obstruction |
title_fullStr | Effect of Collateral Flow on Catheter-Based Assessment of Cardiac Microvascular Obstruction |
title_full_unstemmed | Effect of Collateral Flow on Catheter-Based Assessment of Cardiac Microvascular Obstruction |
title_short | Effect of Collateral Flow on Catheter-Based Assessment of Cardiac Microvascular Obstruction |
title_sort | effect of collateral flow on catheter-based assessment of cardiac microvascular obstruction |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363345/ https://www.ncbi.nlm.nih.gov/pubmed/35639221 http://dx.doi.org/10.1007/s10439-022-02985-2 |
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