GFAT1-linked TAB1 glutamylation sustains p38 MAPK activation and promotes lung cancer cell survival under glucose starvation

Reprogrammed cell metabolism is deemed as one of the hallmarks of cancer. Hexosamine biosynthesis pathway (HBP) acts as an “energy sensor” in cells to regulate metabolic fluxes. Glutamine-fructose-6-phosphate amidotransferase 1 (GFAT1), the rate-limiting enzyme of HBP, is broadly found with elevated...

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Detalles Bibliográficos
Autores principales: Wei, Shupei, Zhao, Qin, Zheng, Ke, Liu, Peiying, Sha, Nannan, Li, Yingzi, Ma, Chunmin, Li, Jingjie, Zhuo, Lingang, Liu, Guanxin, Liang, Wenhua, Jiang, Yuhui, Chen, Tao, Zhong, Nanshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363421/
https://www.ncbi.nlm.nih.gov/pubmed/35945223
http://dx.doi.org/10.1038/s41421-022-00423-0

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