Structural and biochemical basis for DNA and RNA catalysis by human Topoisomerase 3β

In metazoans, topoisomerase 3β (TOP3B) regulates R-loop dynamics and mRNA translation, which are critical for genome stability, neurodevelopment and normal aging. As a Type IA topoisomerase, TOP3B acts by general acid-base catalysis to break and rejoin single-stranded DNA. Passage of a second DNA st...

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Detalles Bibliográficos
Autores principales: Yang, Xi, Saha, Sourav, Yang, Wei, Neuman, Keir C., Pommier, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363430/
https://www.ncbi.nlm.nih.gov/pubmed/35945419
http://dx.doi.org/10.1038/s41467-022-32221-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363430/
https://www.ncbi.nlm.nih.gov/pubmed/35945419
http://dx.doi.org/10.1038/s41467-022-32221-3

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