Pro-oxidant response and accelerated ferroptosis caused by synergetic Au(I) release in hypercarbon-centered gold(I) cluster prodrugs

Medicinal applications of gold complexes have recently attracted attention due to their innovative antitumor mechanisms. In this work, two hypercoordinated carbon-centered gold clusters PAA4 and PAA5 are quantitatively synthesized by an intramolecular 6-exo-dig cyclization of polymetalated precursor...

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Detalles Bibliográficos
Autores principales: Xiao, Kui, Zhang, Niyuan, Li, Feifei, Hou, Dayong, Zhai, Xiaoyi, Xu, Wanhai, Wang, Gelin, Wang, Hao, Zhao, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363434/
https://www.ncbi.nlm.nih.gov/pubmed/35945240
http://dx.doi.org/10.1038/s41467-022-32474-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363434/
https://www.ncbi.nlm.nih.gov/pubmed/35945240
http://dx.doi.org/10.1038/s41467-022-32474-y

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