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Lipids in cancer: a global view of the contribution of lipid pathways to metastatic formation and treatment resistance
Lipids are essential constituents for malignant tumors, as they are absolutely required for tumor growth and dissemination. Provided by the tumor microenvironment (TME) or by cancer cells themselves through activation of de novo synthesis pathways, they orchestrate a large variety of pro-tumorigenic...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363460/ https://www.ncbi.nlm.nih.gov/pubmed/35945203 http://dx.doi.org/10.1038/s41389-022-00420-8 |
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author | Vasseur, Sophie Guillaumond, Fabienne |
author_facet | Vasseur, Sophie Guillaumond, Fabienne |
author_sort | Vasseur, Sophie |
collection | PubMed |
description | Lipids are essential constituents for malignant tumors, as they are absolutely required for tumor growth and dissemination. Provided by the tumor microenvironment (TME) or by cancer cells themselves through activation of de novo synthesis pathways, they orchestrate a large variety of pro-tumorigenic functions. Importantly, TME cells, especially immune cells, cancer-associated fibroblasts (CAFs) and cancer-associated adipocytes (CAAs), are also prone to changes in their lipid content, which hinder or promote tumor aggressiveness. In this review, we address the significant findings for lipid contribution in tumor progression towards a metastatic disease and in the poor response to therapeutic treatments. We also highlight the benefits of targeting lipid pathways in preclinical models to slow down metastasis development and overcome chemo-and immunotherapy resistance. |
format | Online Article Text |
id | pubmed-9363460 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-93634602022-08-11 Lipids in cancer: a global view of the contribution of lipid pathways to metastatic formation and treatment resistance Vasseur, Sophie Guillaumond, Fabienne Oncogenesis Review Article Lipids are essential constituents for malignant tumors, as they are absolutely required for tumor growth and dissemination. Provided by the tumor microenvironment (TME) or by cancer cells themselves through activation of de novo synthesis pathways, they orchestrate a large variety of pro-tumorigenic functions. Importantly, TME cells, especially immune cells, cancer-associated fibroblasts (CAFs) and cancer-associated adipocytes (CAAs), are also prone to changes in their lipid content, which hinder or promote tumor aggressiveness. In this review, we address the significant findings for lipid contribution in tumor progression towards a metastatic disease and in the poor response to therapeutic treatments. We also highlight the benefits of targeting lipid pathways in preclinical models to slow down metastasis development and overcome chemo-and immunotherapy resistance. Nature Publishing Group UK 2022-08-09 /pmc/articles/PMC9363460/ /pubmed/35945203 http://dx.doi.org/10.1038/s41389-022-00420-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Article Vasseur, Sophie Guillaumond, Fabienne Lipids in cancer: a global view of the contribution of lipid pathways to metastatic formation and treatment resistance |
title | Lipids in cancer: a global view of the contribution of lipid pathways to metastatic formation and treatment resistance |
title_full | Lipids in cancer: a global view of the contribution of lipid pathways to metastatic formation and treatment resistance |
title_fullStr | Lipids in cancer: a global view of the contribution of lipid pathways to metastatic formation and treatment resistance |
title_full_unstemmed | Lipids in cancer: a global view of the contribution of lipid pathways to metastatic formation and treatment resistance |
title_short | Lipids in cancer: a global view of the contribution of lipid pathways to metastatic formation and treatment resistance |
title_sort | lipids in cancer: a global view of the contribution of lipid pathways to metastatic formation and treatment resistance |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363460/ https://www.ncbi.nlm.nih.gov/pubmed/35945203 http://dx.doi.org/10.1038/s41389-022-00420-8 |
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