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Celsr3 Inactivation in the Brainstem Impairs Rubrospinal Tract Development and Mouse Behaviors in Motor Coordination and Mechanic-Induced Response

Inactivation of Celsr3 in the forebrain results in defects of longitudinal axonal tracts such as the corticospinal tract. In this study, we inactivated Celsr3 in the brainstem using En1-Cre mice (Celsr3 cKO) and analyzed axonal and behavioral phenotypes. Celsr3 cKO animals showed an 83% reduction of...

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Detalles Bibliográficos
Autores principales:	Chen, Boli, Li, Fuxiang, Jia, Bin, So, Kwok-Fai, Wei, Ji-An, Liu, Yuchu, Qu, Yibo, Zhou, Libing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363480/ https://www.ncbi.nlm.nih.gov/pubmed/35678978 http://dx.doi.org/10.1007/s12035-022-02910-7

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