C-terminal truncation modulates α-Synuclein’s cytotoxicity and aggregation by promoting the interactions with membrane and chaperone

α-Synuclein (α-syn) is the main protein component of Lewy bodies, the major pathological hallmarks of Parkinson’s disease (PD). C-terminally truncated α-syn is found in the brain of PD patients, reduces cell viability and tends to form fibrils. Nevertheless, little is known about the mechanisms unde...

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Detalles Bibliográficos
Autores principales: Zhang, Cai, Pei, Yunshan, Zhang, Zeting, Xu, Lingling, Liu, Xiaoli, Jiang, Ling, Pielak, Gary J., Zhou, Xin, Liu, Maili, Li, Conggang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363494/
https://www.ncbi.nlm.nih.gov/pubmed/35945337
http://dx.doi.org/10.1038/s42003-022-03768-0

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