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Evaluation of the stability and intratumoral delivery of foreign transgenes encoded by an oncolytic Foamy Virus vector

Foamy Viruses are cell cycle-dependent retroviruses capable of persisting unintegrated in quiescent cells until cell division occurs. This unique ability allows them to target slowly dividing human tumor cells which remains an unmet need in oncolytic virotherapy. We have previously reported the gene...

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Detalles Bibliográficos
Autores principales: Budzik, Karol M., Nace, Rebecca A., Ikeda, Yasuhiro, Russell, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363555/
https://www.ncbi.nlm.nih.gov/pubmed/35145270
http://dx.doi.org/10.1038/s41417-022-00431-y