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Future Fertility of Patients With No Embryo Transfer in Their First IVF Cycle Attempts
OBJECTIVE: We aimed to evaluate the future outcomes of patients undergoing their first IVF (in vitro fertilization) attempt with no oocyte retrieved, no normal zygotes formed, or no embryos available for transfer and to identify factors affecting the live birth rate. METHODS: Patients who underwent...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363566/ https://www.ncbi.nlm.nih.gov/pubmed/35966059 http://dx.doi.org/10.3389/fendo.2022.893506 |
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author | Zhu, Xuli Cao, Mingya Yao, Zhaohui Lu, Peiyang Xu, Yueming Hao, Guimin Zhao, Zhiming |
author_facet | Zhu, Xuli Cao, Mingya Yao, Zhaohui Lu, Peiyang Xu, Yueming Hao, Guimin Zhao, Zhiming |
author_sort | Zhu, Xuli |
collection | PubMed |
description | OBJECTIVE: We aimed to evaluate the future outcomes of patients undergoing their first IVF (in vitro fertilization) attempt with no oocyte retrieved, no normal zygotes formed, or no embryos available for transfer and to identify factors affecting the live birth rate. METHODS: Patients who underwent no transplantable embryo in their first IVF cycles but carried out several consecutive cycles between January 2012 to December 2020 were retrospectively enrolled and divided into three groups:group A (no egg retrieval), group B (no normal zygotes formed), and group C (no embryos available to transfer). The patients were also divided into the live birth group and non-live birth group according to whether they got a live baby or not. The clinical data and the cumulative clinical outcomes of groups were compared. RESULTS: 496 patients met the inclusion criteria and enrolled, with 121 patients with no oocytes retrieved in group A, 138 patients with no normal zygotes formed in group B, and 237 patients with no embryos available to transfer in group C. The age [(34.75(5.82) vs 31.91(5.31), P<0.001; 34.75(5.82) vs 32.25(5.72), P<0.001)] and baseline FSH level [(13.04(8.82) vs 10.52(7.39), P=0.005; 13.04(8.82) vs 9.91(5.95), P<0.001)] of women in group A were significantly higher than those in groups B and C. The stable cumulative live birth rate/patient of three groups achieved 18.18% (after 5 cycles, group A), 28.98% (after 3 cycles, group B) and 20.25% (after 7 cycles, group C). Moreover, the multivariate regression analysis showed that female age and basic FSH were main factors affecting live birth outcome of patients with no embryo transfer in their first IVF cycle attempts. CONCLUSIONS: The future clinical outcome may be better in women with no normal zygotes than those with no oocyte retrieved or no available embryo at their first IVF cycle attempts. The main factors influencing the live birth are age and ovarian reserve. |
format | Online Article Text |
id | pubmed-9363566 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93635662022-08-11 Future Fertility of Patients With No Embryo Transfer in Their First IVF Cycle Attempts Zhu, Xuli Cao, Mingya Yao, Zhaohui Lu, Peiyang Xu, Yueming Hao, Guimin Zhao, Zhiming Front Endocrinol (Lausanne) Endocrinology OBJECTIVE: We aimed to evaluate the future outcomes of patients undergoing their first IVF (in vitro fertilization) attempt with no oocyte retrieved, no normal zygotes formed, or no embryos available for transfer and to identify factors affecting the live birth rate. METHODS: Patients who underwent no transplantable embryo in their first IVF cycles but carried out several consecutive cycles between January 2012 to December 2020 were retrospectively enrolled and divided into three groups:group A (no egg retrieval), group B (no normal zygotes formed), and group C (no embryos available to transfer). The patients were also divided into the live birth group and non-live birth group according to whether they got a live baby or not. The clinical data and the cumulative clinical outcomes of groups were compared. RESULTS: 496 patients met the inclusion criteria and enrolled, with 121 patients with no oocytes retrieved in group A, 138 patients with no normal zygotes formed in group B, and 237 patients with no embryos available to transfer in group C. The age [(34.75(5.82) vs 31.91(5.31), P<0.001; 34.75(5.82) vs 32.25(5.72), P<0.001)] and baseline FSH level [(13.04(8.82) vs 10.52(7.39), P=0.005; 13.04(8.82) vs 9.91(5.95), P<0.001)] of women in group A were significantly higher than those in groups B and C. The stable cumulative live birth rate/patient of three groups achieved 18.18% (after 5 cycles, group A), 28.98% (after 3 cycles, group B) and 20.25% (after 7 cycles, group C). Moreover, the multivariate regression analysis showed that female age and basic FSH were main factors affecting live birth outcome of patients with no embryo transfer in their first IVF cycle attempts. CONCLUSIONS: The future clinical outcome may be better in women with no normal zygotes than those with no oocyte retrieved or no available embryo at their first IVF cycle attempts. The main factors influencing the live birth are age and ovarian reserve. Frontiers Media S.A. 2022-07-27 /pmc/articles/PMC9363566/ /pubmed/35966059 http://dx.doi.org/10.3389/fendo.2022.893506 Text en Copyright © 2022 Zhu, Cao, Yao, Lu, Xu, Hao and Zhao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Zhu, Xuli Cao, Mingya Yao, Zhaohui Lu, Peiyang Xu, Yueming Hao, Guimin Zhao, Zhiming Future Fertility of Patients With No Embryo Transfer in Their First IVF Cycle Attempts |
title | Future Fertility of Patients With No Embryo Transfer in Their First IVF Cycle Attempts |
title_full | Future Fertility of Patients With No Embryo Transfer in Their First IVF Cycle Attempts |
title_fullStr | Future Fertility of Patients With No Embryo Transfer in Their First IVF Cycle Attempts |
title_full_unstemmed | Future Fertility of Patients With No Embryo Transfer in Their First IVF Cycle Attempts |
title_short | Future Fertility of Patients With No Embryo Transfer in Their First IVF Cycle Attempts |
title_sort | future fertility of patients with no embryo transfer in their first ivf cycle attempts |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363566/ https://www.ncbi.nlm.nih.gov/pubmed/35966059 http://dx.doi.org/10.3389/fendo.2022.893506 |
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