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Calciphylaxis in End-Stage Renal Disease: A Rare Condition With High Mortality

Calciphylaxis is a rare but life-threatening condition, seen in patients with end-stage renal disease (ESRD) on renal replacement therapy. Its pathogenesis is not completely known, but microvascular calcification and thrombosis are considered the likely processes. It is characterized by significant...

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Autores principales: Bachu, Ramya, Patel, Tanvi H, Hemmings, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363687/
https://www.ncbi.nlm.nih.gov/pubmed/35967146
http://dx.doi.org/10.7759/cureus.26752
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author Bachu, Ramya
Patel, Tanvi H
Hemmings, Stefan
author_facet Bachu, Ramya
Patel, Tanvi H
Hemmings, Stefan
author_sort Bachu, Ramya
collection PubMed
description Calciphylaxis is a rare but life-threatening condition, seen in patients with end-stage renal disease (ESRD) on renal replacement therapy. Its pathogenesis is not completely known, but microvascular calcification and thrombosis are considered the likely processes. It is characterized by significant morbidity due to severe pain and nonhealing wounds with frequent hospitalizations. Sepsis is the most common cause of mortality with more than 50% of patients dying within the first year after diagnosis. Optimal management requires a multidisciplinary approach. We describe a case of a 66-year-old female with ESRD on hemodialysis (HD) who presented with severe progressive calciphylaxis wounds on both lower extremities and died within two months after diagnosis. She had multiple admissions in the past for cellulitis when she presented with swelling in the legs and chronic wounds. Our goal is to increase awareness among physicians to include calciphylaxis in their differential diagnosis when treating ESRD patients with significant risk factors to detect it early and prevent morbidity and mortality.
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spelling pubmed-93636872022-08-11 Calciphylaxis in End-Stage Renal Disease: A Rare Condition With High Mortality Bachu, Ramya Patel, Tanvi H Hemmings, Stefan Cureus Internal Medicine Calciphylaxis is a rare but life-threatening condition, seen in patients with end-stage renal disease (ESRD) on renal replacement therapy. Its pathogenesis is not completely known, but microvascular calcification and thrombosis are considered the likely processes. It is characterized by significant morbidity due to severe pain and nonhealing wounds with frequent hospitalizations. Sepsis is the most common cause of mortality with more than 50% of patients dying within the first year after diagnosis. Optimal management requires a multidisciplinary approach. We describe a case of a 66-year-old female with ESRD on hemodialysis (HD) who presented with severe progressive calciphylaxis wounds on both lower extremities and died within two months after diagnosis. She had multiple admissions in the past for cellulitis when she presented with swelling in the legs and chronic wounds. Our goal is to increase awareness among physicians to include calciphylaxis in their differential diagnosis when treating ESRD patients with significant risk factors to detect it early and prevent morbidity and mortality. Cureus 2022-07-11 /pmc/articles/PMC9363687/ /pubmed/35967146 http://dx.doi.org/10.7759/cureus.26752 Text en Copyright © 2022, Bachu et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Bachu, Ramya
Patel, Tanvi H
Hemmings, Stefan
Calciphylaxis in End-Stage Renal Disease: A Rare Condition With High Mortality
title Calciphylaxis in End-Stage Renal Disease: A Rare Condition With High Mortality
title_full Calciphylaxis in End-Stage Renal Disease: A Rare Condition With High Mortality
title_fullStr Calciphylaxis in End-Stage Renal Disease: A Rare Condition With High Mortality
title_full_unstemmed Calciphylaxis in End-Stage Renal Disease: A Rare Condition With High Mortality
title_short Calciphylaxis in End-Stage Renal Disease: A Rare Condition With High Mortality
title_sort calciphylaxis in end-stage renal disease: a rare condition with high mortality
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363687/
https://www.ncbi.nlm.nih.gov/pubmed/35967146
http://dx.doi.org/10.7759/cureus.26752
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