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Potential Implications of the Lung Microbiota in Patients with Chronic Obstruction Pulmonary Disease and Non-Small Cell Lung Cancer

Recently, chronic obstructive pulmonary disease (COPD) has been considered as a common risk factor of non-small cell lung cancer (NSCLC). However, very few studies have been conducted on the effects of COPD on the lung microbiota in patients with NSCLC. To identify the lung microbiota in patients wi...

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Autores principales: He, Jia-Qi, Chen, Qin, Wu, Sheng-Jun, Wang, De-Qin, Zhang, Shen-Yingjie, Zhang, Song-Zhao, Chen, Rui-Lin, Wang, Jia-Feng, Wang, Zhen, Yu, Chen-Huan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363884/
https://www.ncbi.nlm.nih.gov/pubmed/35967848
http://dx.doi.org/10.3389/fcimb.2022.937864
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author He, Jia-Qi
Chen, Qin
Wu, Sheng-Jun
Wang, De-Qin
Zhang, Shen-Yingjie
Zhang, Song-Zhao
Chen, Rui-Lin
Wang, Jia-Feng
Wang, Zhen
Yu, Chen-Huan
author_facet He, Jia-Qi
Chen, Qin
Wu, Sheng-Jun
Wang, De-Qin
Zhang, Shen-Yingjie
Zhang, Song-Zhao
Chen, Rui-Lin
Wang, Jia-Feng
Wang, Zhen
Yu, Chen-Huan
author_sort He, Jia-Qi
collection PubMed
description Recently, chronic obstructive pulmonary disease (COPD) has been considered as a common risk factor of non-small cell lung cancer (NSCLC). However, very few studies have been conducted on the effects of COPD on the lung microbiota in patients with NSCLC. To identify the lung microbiota in patients with COPD and NSCLC (CN), the microbiome of the induced sputa of 90 patients was analyzed using 16S rDNA sequencing. The results showed no significant differences in the bacterial diversities of induced sputa among patients with COPD, NSCLC, and CN and no intrinsic differences among patients with different pathological types of lung cancer. After surgical operation, the diversities of the induced sputa in patients with CN significantly decreased. More remarkably, both the microbial community phenotypes and the components of the induced sputa in patients with CN obviously differed from those in patients with COPD or NSCLC. The relative abundances of Streptococcus, Veillonella, Moraxella, and Actinomyces significantly decreased, but those of Neisseria and Acinetobacter significantly increased in patients with CN compared with those in patients with COPD or NSCLC alone, resulting in increased Gram-negative microbiota and, therefore, in potential pathogenicity and stress tolerance, as well as in enhancement of microbial glycolipid metabolism, amino acid metabolism, and oxidative stress. Although COPD did not affect the number of pulmonary flora species in patients with NSCLC, these significant alterations in the microbial populations, phenotypes, and functions of induced sputa due to COPD would contribute to inflammation-derived cancer progression in patients with CN.
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spelling pubmed-93638842022-08-11 Potential Implications of the Lung Microbiota in Patients with Chronic Obstruction Pulmonary Disease and Non-Small Cell Lung Cancer He, Jia-Qi Chen, Qin Wu, Sheng-Jun Wang, De-Qin Zhang, Shen-Yingjie Zhang, Song-Zhao Chen, Rui-Lin Wang, Jia-Feng Wang, Zhen Yu, Chen-Huan Front Cell Infect Microbiol Cellular and Infection Microbiology Recently, chronic obstructive pulmonary disease (COPD) has been considered as a common risk factor of non-small cell lung cancer (NSCLC). However, very few studies have been conducted on the effects of COPD on the lung microbiota in patients with NSCLC. To identify the lung microbiota in patients with COPD and NSCLC (CN), the microbiome of the induced sputa of 90 patients was analyzed using 16S rDNA sequencing. The results showed no significant differences in the bacterial diversities of induced sputa among patients with COPD, NSCLC, and CN and no intrinsic differences among patients with different pathological types of lung cancer. After surgical operation, the diversities of the induced sputa in patients with CN significantly decreased. More remarkably, both the microbial community phenotypes and the components of the induced sputa in patients with CN obviously differed from those in patients with COPD or NSCLC. The relative abundances of Streptococcus, Veillonella, Moraxella, and Actinomyces significantly decreased, but those of Neisseria and Acinetobacter significantly increased in patients with CN compared with those in patients with COPD or NSCLC alone, resulting in increased Gram-negative microbiota and, therefore, in potential pathogenicity and stress tolerance, as well as in enhancement of microbial glycolipid metabolism, amino acid metabolism, and oxidative stress. Although COPD did not affect the number of pulmonary flora species in patients with NSCLC, these significant alterations in the microbial populations, phenotypes, and functions of induced sputa due to COPD would contribute to inflammation-derived cancer progression in patients with CN. Frontiers Media S.A. 2022-07-27 /pmc/articles/PMC9363884/ /pubmed/35967848 http://dx.doi.org/10.3389/fcimb.2022.937864 Text en Copyright © 2022 He, Chen, Wu, Wang, Zhang, Zhang, Chen, Wang, Wang and Yu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
He, Jia-Qi
Chen, Qin
Wu, Sheng-Jun
Wang, De-Qin
Zhang, Shen-Yingjie
Zhang, Song-Zhao
Chen, Rui-Lin
Wang, Jia-Feng
Wang, Zhen
Yu, Chen-Huan
Potential Implications of the Lung Microbiota in Patients with Chronic Obstruction Pulmonary Disease and Non-Small Cell Lung Cancer
title Potential Implications of the Lung Microbiota in Patients with Chronic Obstruction Pulmonary Disease and Non-Small Cell Lung Cancer
title_full Potential Implications of the Lung Microbiota in Patients with Chronic Obstruction Pulmonary Disease and Non-Small Cell Lung Cancer
title_fullStr Potential Implications of the Lung Microbiota in Patients with Chronic Obstruction Pulmonary Disease and Non-Small Cell Lung Cancer
title_full_unstemmed Potential Implications of the Lung Microbiota in Patients with Chronic Obstruction Pulmonary Disease and Non-Small Cell Lung Cancer
title_short Potential Implications of the Lung Microbiota in Patients with Chronic Obstruction Pulmonary Disease and Non-Small Cell Lung Cancer
title_sort potential implications of the lung microbiota in patients with chronic obstruction pulmonary disease and non-small cell lung cancer
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363884/
https://www.ncbi.nlm.nih.gov/pubmed/35967848
http://dx.doi.org/10.3389/fcimb.2022.937864
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