Effect of water-soluble fullerenes on macrophage surface ultrastructure revealed by scanning ion conductance microscopy

C(60)-fullerenes have unique potential in antiviral, drug delivery, photodynamic therapy and other biomedical applications. However, little is known about their effects on macrophage surface morphology and ultrastructure. Here by using contact-free scanning ion conductance microscopy (SICM), we inve...

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Detalles Bibliográficos
Autores principales: Ruan, Hefei, Zhang, Xuejie, Yuan, Jinghe, Fang, Xiaohong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364078/
https://www.ncbi.nlm.nih.gov/pubmed/36043103
http://dx.doi.org/10.1039/d2ra02403a
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author Ruan, Hefei
Zhang, Xuejie
Yuan, Jinghe
Fang, Xiaohong
author_facet Ruan, Hefei
Zhang, Xuejie
Yuan, Jinghe
Fang, Xiaohong
author_sort Ruan, Hefei
collection PubMed
description C(60)-fullerenes have unique potential in antiviral, drug delivery, photodynamic therapy and other biomedical applications. However, little is known about their effects on macrophage surface morphology and ultrastructure. Here by using contact-free scanning ion conductance microscopy (SICM), we investigated the effects of two water-soluble fullerenes on the surface ultrastructure and function of macrophages. The results showed that these fullerenes would be a promising phagocytosis inhibitor and SICM would be an excellent tool to study the morphological information of adhesive and fragile samples.
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spelling pubmed-93640782022-08-29 Effect of water-soluble fullerenes on macrophage surface ultrastructure revealed by scanning ion conductance microscopy Ruan, Hefei Zhang, Xuejie Yuan, Jinghe Fang, Xiaohong RSC Adv Chemistry C(60)-fullerenes have unique potential in antiviral, drug delivery, photodynamic therapy and other biomedical applications. However, little is known about their effects on macrophage surface morphology and ultrastructure. Here by using contact-free scanning ion conductance microscopy (SICM), we investigated the effects of two water-soluble fullerenes on the surface ultrastructure and function of macrophages. The results showed that these fullerenes would be a promising phagocytosis inhibitor and SICM would be an excellent tool to study the morphological information of adhesive and fragile samples. The Royal Society of Chemistry 2022-08-10 /pmc/articles/PMC9364078/ /pubmed/36043103 http://dx.doi.org/10.1039/d2ra02403a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Ruan, Hefei
Zhang, Xuejie
Yuan, Jinghe
Fang, Xiaohong
Effect of water-soluble fullerenes on macrophage surface ultrastructure revealed by scanning ion conductance microscopy
title Effect of water-soluble fullerenes on macrophage surface ultrastructure revealed by scanning ion conductance microscopy
title_full Effect of water-soluble fullerenes on macrophage surface ultrastructure revealed by scanning ion conductance microscopy
title_fullStr Effect of water-soluble fullerenes on macrophage surface ultrastructure revealed by scanning ion conductance microscopy
title_full_unstemmed Effect of water-soluble fullerenes on macrophage surface ultrastructure revealed by scanning ion conductance microscopy
title_short Effect of water-soluble fullerenes on macrophage surface ultrastructure revealed by scanning ion conductance microscopy
title_sort effect of water-soluble fullerenes on macrophage surface ultrastructure revealed by scanning ion conductance microscopy
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364078/
https://www.ncbi.nlm.nih.gov/pubmed/36043103
http://dx.doi.org/10.1039/d2ra02403a
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AT zhangxuejie effectofwatersolublefullerenesonmacrophagesurfaceultrastructurerevealedbyscanningionconductancemicroscopy
AT yuanjinghe effectofwatersolublefullerenesonmacrophagesurfaceultrastructurerevealedbyscanningionconductancemicroscopy
AT fangxiaohong effectofwatersolublefullerenesonmacrophagesurfaceultrastructurerevealedbyscanningionconductancemicroscopy

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