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A small molecule toll-like receptor antagonist rescues α-synuclein fibril pathology

The propagation and accumulation of pathological α-synuclein protein is thought to underlie the clinical symptoms of the neurodegenerative movement disorder Parkinson’s disease (PD). Consequently, there is significant interest in identifying the mechanisms that contribute to α-synuclein pathology, a...

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Detalles Bibliográficos
Autores principales:	Chedid, Jessica, Labrador-Garrido, Adahir, Zhong, Siying, Gao, Jianqun, Zhao, Ye, Perera, Gayathri, Kim, Woojin S., Halliday, Glenda M., Dzamko, Nicolas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364105/ https://www.ncbi.nlm.nih.gov/pubmed/35841928 http://dx.doi.org/10.1016/j.jbc.2022.102260

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