Unraveling the toxic effects mediated by the neurodegenerative disease–associated S375G mutation of TDP-43 and its S375E phosphomimetic variant

TAR DNA-binding protein 43 (TDP-43) is a nucleic acid–binding protein found in the nucleus that accumulates in the cytoplasm under pathological conditions, leading to proteinopathies, such as frontotemporal dementia and ALS. An emerging area of TDP-43 research is represented by the study of its post...

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Detalles Bibliográficos
Autores principales: Paron, Francesca, Barattucci, Simone, Cappelli, Sara, Romano, Maurizio, Berlingieri, Christian, Stuani, Cristiana, Laurents, Douglas, Mompeán, Miguel, Buratti, Emanuele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364110/
https://www.ncbi.nlm.nih.gov/pubmed/35835219
http://dx.doi.org/10.1016/j.jbc.2022.102252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364110/
https://www.ncbi.nlm.nih.gov/pubmed/35835219
http://dx.doi.org/10.1016/j.jbc.2022.102252

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