The role of interleukin-22 in lung health and its therapeutic potential for COVID-19

Although numerous clinical trials have been implemented, an absolutely effective treatment against coronavirus disease 2019 (COVID-19) is still elusive. Interleukin-22 (IL-22) has attracted great interest over recent years, making it one of the best-studied cytokines of the interleukin-10 (IL-10) fa...

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Autores principales: Fang, Si, Ju, Dianwen, Lin, Yong, Chen, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364265/
https://www.ncbi.nlm.nih.gov/pubmed/35967401
http://dx.doi.org/10.3389/fimmu.2022.951107
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author Fang, Si
Ju, Dianwen
Lin, Yong
Chen, Wei
author_facet Fang, Si
Ju, Dianwen
Lin, Yong
Chen, Wei
author_sort Fang, Si
collection PubMed
description Although numerous clinical trials have been implemented, an absolutely effective treatment against coronavirus disease 2019 (COVID-19) is still elusive. Interleukin-22 (IL-22) has attracted great interest over recent years, making it one of the best-studied cytokines of the interleukin-10 (IL-10) family. Unlike most interleukins, the major impact of IL-22 is exclusively on fibroblasts and epithelial cells due to the restricted expression of receptor. Numerous studies have suggested that IL-22 plays a crucial role in anti-viral infections through significantly ameliorating the immune cell-mediated inflammatory responses, and reducing tissue injury as well as further promoting epithelial repair and regeneration. Herein, we pay special attention to the role of IL-22 in the lungs. We summarize the latest progress in our understanding of IL-22 in lung health and disease and further discuss maneuvering this cytokine as potential immunotherapeutic strategy for the effective manage of COVID-19.
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spelling pubmed-93642652022-08-11 The role of interleukin-22 in lung health and its therapeutic potential for COVID-19 Fang, Si Ju, Dianwen Lin, Yong Chen, Wei Front Immunol Immunology Although numerous clinical trials have been implemented, an absolutely effective treatment against coronavirus disease 2019 (COVID-19) is still elusive. Interleukin-22 (IL-22) has attracted great interest over recent years, making it one of the best-studied cytokines of the interleukin-10 (IL-10) family. Unlike most interleukins, the major impact of IL-22 is exclusively on fibroblasts and epithelial cells due to the restricted expression of receptor. Numerous studies have suggested that IL-22 plays a crucial role in anti-viral infections through significantly ameliorating the immune cell-mediated inflammatory responses, and reducing tissue injury as well as further promoting epithelial repair and regeneration. Herein, we pay special attention to the role of IL-22 in the lungs. We summarize the latest progress in our understanding of IL-22 in lung health and disease and further discuss maneuvering this cytokine as potential immunotherapeutic strategy for the effective manage of COVID-19. Frontiers Media S.A. 2022-07-27 /pmc/articles/PMC9364265/ /pubmed/35967401 http://dx.doi.org/10.3389/fimmu.2022.951107 Text en Copyright © 2022 Fang, Ju, Lin and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Fang, Si
Ju, Dianwen
Lin, Yong
Chen, Wei
The role of interleukin-22 in lung health and its therapeutic potential for COVID-19
title The role of interleukin-22 in lung health and its therapeutic potential for COVID-19
title_full The role of interleukin-22 in lung health and its therapeutic potential for COVID-19
title_fullStr The role of interleukin-22 in lung health and its therapeutic potential for COVID-19
title_full_unstemmed The role of interleukin-22 in lung health and its therapeutic potential for COVID-19
title_short The role of interleukin-22 in lung health and its therapeutic potential for COVID-19
title_sort role of interleukin-22 in lung health and its therapeutic potential for covid-19
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364265/
https://www.ncbi.nlm.nih.gov/pubmed/35967401
http://dx.doi.org/10.3389/fimmu.2022.951107
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