New dimeric chromanone derivatives from the mutant strains of Penicillium oxalicum and their bioactivities

Three new chromanone dimer derivatives, paecilins F–H (1–3) and ten known compounds (4–13), were obtained from the mutant strains of Penicillium oxalicum 114-2. Their structures were elucidated by extensive analysis of spectroscopic data and comparison with reported data, and the configurations of 1...

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Detalles Bibliográficos
Autores principales: Gu, Guowei, Zhang, Tao, Zhao, Jianyuan, Zhao, Wuli, Tang, Yan, Wang, Lu, Cen, Shan, Yu, Liyan, Zhang, Dewu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364356/
https://www.ncbi.nlm.nih.gov/pubmed/36105983
http://dx.doi.org/10.1039/d2ra02639b
Descripción
Sumario:Three new chromanone dimer derivatives, paecilins F–H (1–3) and ten known compounds (4–13), were obtained from the mutant strains of Penicillium oxalicum 114-2. Their structures were elucidated by extensive analysis of spectroscopic data and comparison with reported data, and the configurations of 1–3 were resolved by quantum chemical calculations of NMR shifts and ECD spectra. Compounds 5 and 11 showed significant anti-influenza A virus activities with IC(50) values of 5.6 and 6.9 μM, respectively. Compounds 8 and 9 displayed cytotoxic activities against the MIA-PaCa-2 cell line with IC(50) values of 2.6 and 2.1 μM, respectively. Compound 10 exhibited antibacterial activities against Bacillus cereus with a MIC value of 4 μg mL(−1).

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