New dimeric chromanone derivatives from the mutant strains of Penicillium oxalicum and their bioactivities

Three new chromanone dimer derivatives, paecilins F–H (1–3) and ten known compounds (4–13), were obtained from the mutant strains of Penicillium oxalicum 114-2. Their structures were elucidated by extensive analysis of spectroscopic data and comparison with reported data, and the configurations of 1...

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Autores principales: Gu, Guowei, Zhang, Tao, Zhao, Jianyuan, Zhao, Wuli, Tang, Yan, Wang, Lu, Cen, Shan, Yu, Liyan, Zhang, Dewu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364356/
https://www.ncbi.nlm.nih.gov/pubmed/36105983
http://dx.doi.org/10.1039/d2ra02639b
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author Gu, Guowei
Zhang, Tao
Zhao, Jianyuan
Zhao, Wuli
Tang, Yan
Wang, Lu
Cen, Shan
Yu, Liyan
Zhang, Dewu
author_facet Gu, Guowei
Zhang, Tao
Zhao, Jianyuan
Zhao, Wuli
Tang, Yan
Wang, Lu
Cen, Shan
Yu, Liyan
Zhang, Dewu
author_sort Gu, Guowei
collection PubMed
description Three new chromanone dimer derivatives, paecilins F–H (1–3) and ten known compounds (4–13), were obtained from the mutant strains of Penicillium oxalicum 114-2. Their structures were elucidated by extensive analysis of spectroscopic data and comparison with reported data, and the configurations of 1–3 were resolved by quantum chemical calculations of NMR shifts and ECD spectra. Compounds 5 and 11 showed significant anti-influenza A virus activities with IC(50) values of 5.6 and 6.9 μM, respectively. Compounds 8 and 9 displayed cytotoxic activities against the MIA-PaCa-2 cell line with IC(50) values of 2.6 and 2.1 μM, respectively. Compound 10 exhibited antibacterial activities against Bacillus cereus with a MIC value of 4 μg mL(−1).
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spelling pubmed-93643562022-09-13 New dimeric chromanone derivatives from the mutant strains of Penicillium oxalicum and their bioactivities Gu, Guowei Zhang, Tao Zhao, Jianyuan Zhao, Wuli Tang, Yan Wang, Lu Cen, Shan Yu, Liyan Zhang, Dewu RSC Adv Chemistry Three new chromanone dimer derivatives, paecilins F–H (1–3) and ten known compounds (4–13), were obtained from the mutant strains of Penicillium oxalicum 114-2. Their structures were elucidated by extensive analysis of spectroscopic data and comparison with reported data, and the configurations of 1–3 were resolved by quantum chemical calculations of NMR shifts and ECD spectra. Compounds 5 and 11 showed significant anti-influenza A virus activities with IC(50) values of 5.6 and 6.9 μM, respectively. Compounds 8 and 9 displayed cytotoxic activities against the MIA-PaCa-2 cell line with IC(50) values of 2.6 and 2.1 μM, respectively. Compound 10 exhibited antibacterial activities against Bacillus cereus with a MIC value of 4 μg mL(−1). The Royal Society of Chemistry 2022-08-10 /pmc/articles/PMC9364356/ /pubmed/36105983 http://dx.doi.org/10.1039/d2ra02639b Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Gu, Guowei
Zhang, Tao
Zhao, Jianyuan
Zhao, Wuli
Tang, Yan
Wang, Lu
Cen, Shan
Yu, Liyan
Zhang, Dewu
New dimeric chromanone derivatives from the mutant strains of Penicillium oxalicum and their bioactivities
title New dimeric chromanone derivatives from the mutant strains of Penicillium oxalicum and their bioactivities
title_full New dimeric chromanone derivatives from the mutant strains of Penicillium oxalicum and their bioactivities
title_fullStr New dimeric chromanone derivatives from the mutant strains of Penicillium oxalicum and their bioactivities
title_full_unstemmed New dimeric chromanone derivatives from the mutant strains of Penicillium oxalicum and their bioactivities
title_short New dimeric chromanone derivatives from the mutant strains of Penicillium oxalicum and their bioactivities
title_sort new dimeric chromanone derivatives from the mutant strains of penicillium oxalicum and their bioactivities
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364356/
https://www.ncbi.nlm.nih.gov/pubmed/36105983
http://dx.doi.org/10.1039/d2ra02639b
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