Jejuketomycins A and B, polyketide glycosides with cancer cell migration inhibitory activity from Streptomyces sp. KCB15JA151

Two new polyketide glycosides jejuketomycins A (1) and B (2), were isolated from a culture of Streptomyces sp. KCB15JA151. Their chemical structures including the absolute configurations were determined by detailed analyses of the NMR and HRMS data and ECD calculations and spectral data. Compounds 1...

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Detalles Bibliográficos
Autores principales: Jang, Jun-Pil, Kim, Gil Soo, Oh, Tae Hoon, Park, Beomcheol, Kim, Minhee, Hwang, Gwi Ja, Lee, Hyeok-Won, Lee, Jin-Gyeom, Hong, Young-Soo, Ahn, Jong Seog, Ko, Sung-Kyun, Jang, Jae-Hyuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364360/
https://www.ncbi.nlm.nih.gov/pubmed/36105948
http://dx.doi.org/10.1039/d2ra04039e
Descripción
Sumario:Two new polyketide glycosides jejuketomycins A (1) and B (2), were isolated from a culture of Streptomyces sp. KCB15JA151. Their chemical structures including the absolute configurations were determined by detailed analyses of the NMR and HRMS data and ECD calculations and spectral data. Compounds 1 and 2 possess an unusual 6/6/8 tricyclic ring system. Biological evaluation with the wound healing assay and time-lapse cell tracking analysis revealed that compounds 1 and 2 have significant inhibitory activities against cancer cell migration with low cytotoxicity.

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