Jejuketomycins A and B, polyketide glycosides with cancer cell migration inhibitory activity from Streptomyces sp. KCB15JA151

Two new polyketide glycosides jejuketomycins A (1) and B (2), were isolated from a culture of Streptomyces sp. KCB15JA151. Their chemical structures including the absolute configurations were determined by detailed analyses of the NMR and HRMS data and ECD calculations and spectral data. Compounds 1...

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Autores principales: Jang, Jun-Pil, Kim, Gil Soo, Oh, Tae Hoon, Park, Beomcheol, Kim, Minhee, Hwang, Gwi Ja, Lee, Hyeok-Won, Lee, Jin-Gyeom, Hong, Young-Soo, Ahn, Jong Seog, Ko, Sung-Kyun, Jang, Jae-Hyuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364360/
https://www.ncbi.nlm.nih.gov/pubmed/36105948
http://dx.doi.org/10.1039/d2ra04039e
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author Jang, Jun-Pil
Kim, Gil Soo
Oh, Tae Hoon
Park, Beomcheol
Kim, Minhee
Hwang, Gwi Ja
Lee, Hyeok-Won
Lee, Jin-Gyeom
Hong, Young-Soo
Ahn, Jong Seog
Ko, Sung-Kyun
Jang, Jae-Hyuk
author_facet Jang, Jun-Pil
Kim, Gil Soo
Oh, Tae Hoon
Park, Beomcheol
Kim, Minhee
Hwang, Gwi Ja
Lee, Hyeok-Won
Lee, Jin-Gyeom
Hong, Young-Soo
Ahn, Jong Seog
Ko, Sung-Kyun
Jang, Jae-Hyuk
author_sort Jang, Jun-Pil
collection PubMed
description Two new polyketide glycosides jejuketomycins A (1) and B (2), were isolated from a culture of Streptomyces sp. KCB15JA151. Their chemical structures including the absolute configurations were determined by detailed analyses of the NMR and HRMS data and ECD calculations and spectral data. Compounds 1 and 2 possess an unusual 6/6/8 tricyclic ring system. Biological evaluation with the wound healing assay and time-lapse cell tracking analysis revealed that compounds 1 and 2 have significant inhibitory activities against cancer cell migration with low cytotoxicity.
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spelling pubmed-93643602022-09-13 Jejuketomycins A and B, polyketide glycosides with cancer cell migration inhibitory activity from Streptomyces sp. KCB15JA151 Jang, Jun-Pil Kim, Gil Soo Oh, Tae Hoon Park, Beomcheol Kim, Minhee Hwang, Gwi Ja Lee, Hyeok-Won Lee, Jin-Gyeom Hong, Young-Soo Ahn, Jong Seog Ko, Sung-Kyun Jang, Jae-Hyuk RSC Adv Chemistry Two new polyketide glycosides jejuketomycins A (1) and B (2), were isolated from a culture of Streptomyces sp. KCB15JA151. Their chemical structures including the absolute configurations were determined by detailed analyses of the NMR and HRMS data and ECD calculations and spectral data. Compounds 1 and 2 possess an unusual 6/6/8 tricyclic ring system. Biological evaluation with the wound healing assay and time-lapse cell tracking analysis revealed that compounds 1 and 2 have significant inhibitory activities against cancer cell migration with low cytotoxicity. The Royal Society of Chemistry 2022-08-10 /pmc/articles/PMC9364360/ /pubmed/36105948 http://dx.doi.org/10.1039/d2ra04039e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Jang, Jun-Pil
Kim, Gil Soo
Oh, Tae Hoon
Park, Beomcheol
Kim, Minhee
Hwang, Gwi Ja
Lee, Hyeok-Won
Lee, Jin-Gyeom
Hong, Young-Soo
Ahn, Jong Seog
Ko, Sung-Kyun
Jang, Jae-Hyuk
Jejuketomycins A and B, polyketide glycosides with cancer cell migration inhibitory activity from Streptomyces sp. KCB15JA151
title Jejuketomycins A and B, polyketide glycosides with cancer cell migration inhibitory activity from Streptomyces sp. KCB15JA151
title_full Jejuketomycins A and B, polyketide glycosides with cancer cell migration inhibitory activity from Streptomyces sp. KCB15JA151
title_fullStr Jejuketomycins A and B, polyketide glycosides with cancer cell migration inhibitory activity from Streptomyces sp. KCB15JA151
title_full_unstemmed Jejuketomycins A and B, polyketide glycosides with cancer cell migration inhibitory activity from Streptomyces sp. KCB15JA151
title_short Jejuketomycins A and B, polyketide glycosides with cancer cell migration inhibitory activity from Streptomyces sp. KCB15JA151
title_sort jejuketomycins a and b, polyketide glycosides with cancer cell migration inhibitory activity from streptomyces sp. kcb15ja151
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364360/
https://www.ncbi.nlm.nih.gov/pubmed/36105948
http://dx.doi.org/10.1039/d2ra04039e
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