Cargando…

Improving candidate Biosynthetic Gene Clusters in fungi through reinforcement learning

MOTIVATION: Precise identification of Biosynthetic Gene Clusters (BGCs) is a challenging task. Performance of BGC discovery tools is limited by their capacity to accurately predict components belonging to candidate BGCs, often overestimating cluster boundaries. To support optimizing the composition...

Descripción completa

Detalles Bibliográficos
Autores principales:	Almeida, Hayda, Tsang, Adrian, Diallo, Abdoulaye Baniré
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Original Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364373/ https://www.ncbi.nlm.nih.gov/pubmed/35762945 http://dx.doi.org/10.1093/bioinformatics/btac420

Ejemplares similares

TOUCAN: a framework for fungal biosynthetic gene cluster discovery
por: Almeida, Hayda, et al.
Publicado: (2020)

Classification of bioinformatics workflows using weighted versions of partitioning and hierarchical clustering algorithms
por: Lord, Etienne, et al.
Publicado: (2015)

Transcriptional Activation of Biosynthetic Gene Clusters in Filamentous Fungi
por: Mózsik, László, et al.
Publicado: (2022)

The evolution of the gliotoxin biosynthetic gene cluster in Penicillium fungi
por: Balamurugan, Charu, et al.
Publicado: (2023)

Phylogenetic Comparison of Swainsonine Biosynthetic Gene Clusters among Fungi
por: Neyaz, Marwa, et al.
Publicado: (2022)

Prediction of human miRNA target genes using computationally reconstructed ancestral mammalian sequences
por: Leclercq, Mickael, et al.
Publicado: (2017)

Detecting and prioritizing biosynthetic gene clusters for bioactive compounds in bacteria and fungi
por: Tran, Phuong Nguyen, et al.
Publicado: (2019)

ProtNN: fast and accurate protein 3D-structure classification in structural and topological space
por: Dhifli, Wajdi, et al.
Publicado: (2016)

Machine Learning for Biomedical Literature Triage
por: Almeida, Hayda, et al.
Publicado: (2014)

Next-generation sequencing approach for connecting secondary metabolites to biosynthetic gene clusters in fungi
por: Cacho, Ralph A., et al.
Publicado: (2015)

Predicting site-specific human selective pressure using evolutionary signatures
por: Sadri, Javad, et al.
Publicado: (2011)

Computational prediction of the localization of microRNAs within their pre-miRNA
por: Leclercq, Mickael, et al.
Publicado: (2013)

Epigenetic Activation of Silent Biosynthetic Gene Clusters in Endophytic Fungi Using Small Molecular Modifiers
por: Pillay, Lynise C., et al.
Publicado: (2022)

A new effective method for estimating missing values in the sequence data prior to phylogenetic analysis
por: Diallo, Abdoulaye Baniré, et al.
Publicado: (2007)

Detecting genomic regions associated with a disease using variability functions and Adjusted Rand Index
por: Badescu, Dunarel, et al.
Publicado: (2011)

A machine learning approach for viral genome classification
por: Remita, Mohamed Amine, et al.
Publicado: (2017)

Editorial: Omics technologies in livestock improvement: From selection to breeding decisions
por: Ahmad, Syed Mudasir, et al.
Publicado: (2023)

Computational Methods for Structure-to-Function Analysis of Diet-Derived Catechins-Mediated Targeting of In Vitro Vasculogenic Mimicry
por: Uthamacumaran, Abicumaran, et al.
Publicado: (2021)

Identification of a Novel Biosynthetic Gene Cluster in Aspergillus niger Using Comparative Genomics
por: Evdokias, Gregory, et al.
Publicado: (2021)

BiosyntheticSPAdes: reconstructing biosynthetic gene clusters from assembly graphs
por: Meleshko, Dmitry, et al.
Publicado: (2019)

Bioprospecting Through Cloning of Whole Natural Product Biosynthetic Gene Clusters
por: Lin, Zhenquan, et al.
Publicado: (2020)

Armadillo 1.1: An Original Workflow Platform for Designing and Conducting Phylogenetic Analysis and Simulations
por: Lord, Etienne, et al.
Publicado: (2012)

Genome-Wide Analysis of Biosynthetic Gene Cluster Reveals Correlated Gene Loss with Absence of Usnic Acid in Lichen-Forming Fungi
por: Pizarro, David, et al.
Publicado: (2020)

Comparative Genomic Analysis of Ochratoxin A Biosynthetic Cluster in Producing Fungi: New Evidence of a Cyclase Gene Involvement
por: Ferrara, Massimo, et al.
Publicado: (2020)

A deep learning genome-mining strategy for biosynthetic gene cluster prediction
por: Hannigan, Geoffrey D, et al.
Publicado: (2019)

Deep self-supervised learning for biosynthetic gene cluster detection and product classification
por: Rios-Martinez, Carolina, et al.
Publicado: (2023)

Sequence analysis of porothramycin biosynthetic gene cluster
por: Najmanova, Lucie, et al.
Publicado: (2014)

Evolution and Diversity of Biosynthetic Gene Clusters in Fusarium
por: Hoogendoorn, Koen, et al.
Publicado: (2018)

Functional Analysis of the Fusarielin Biosynthetic Gene Cluster
por: Droce, Aida, et al.
Publicado: (2016)

Mining biosynthetic gene clusters in Virgibacillus genomes
por: Othoum, Ghofran, et al.
Publicado: (2019)

In silico analyses of maleidride biosynthetic gene clusters
por: Williams, Katherine, et al.
Publicado: (2022)

Multiplexed mobilization and expression of biosynthetic gene clusters
por: Libis, Vincent, et al.
Publicado: (2022)

Genome Sequencing and analyses of Two Marine Fungi from the North Sea Unraveled a Plethora of Novel Biosynthetic Gene Clusters
por: Kumar, Abhishek, et al.
Publicado: (2018)

Survey of Biosynthetic Gene Clusters from Sequenced Myxobacteria Reveals Unexplored Biosynthetic Potential
por: Gregory, Katherine, et al.
Publicado: (2019)

Ancient Horizontal Gene Transfer from Bacteria Enhances Biosynthetic Capabilities of Fungi
por: Schmitt, Imke, et al.
Publicado: (2009)

Evolution-Informed Discovery of the Naphthalenone Biosynthetic Pathway in Fungi
por: Mosunova, Olga V., et al.
Publicado: (2022)

Insights into rumen microbial biosynthetic gene cluster diversity through genome-resolved metagenomics
por: Anderson, Christopher L., et al.
Publicado: (2021)

Identification of the Scopularide Biosynthetic Gene Cluster in Scopulariopsis brevicaulis
por: Lukassen, Mie Bech, et al.
Publicado: (2015)

New Approaches to Detect Biosynthetic Gene Clusters in the Environment
por: Chen, Ray, et al.
Publicado: (2019)

The Biosynthetic Gene Cluster for Andrastin A in Penicillium roqueforti
por: Rojas-Aedo, Juan F., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_viq26cthqo6jhpl2s6jlu0htth