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Dopamine systems and biological rhythms: Let’s get a move on

How dopamine signaling regulates biological rhythms is an area of emerging interest. Here we review experiments focused on delineating dopamine signaling in the suprachiasmatic nucleus, nucleus accumbens, and dorsal striatum to mediate a range of biological rhythms including photoentrainment, activi...

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Autores principales: Tang, Qijun, Assali, Dina R., Güler, Ali D., Steele, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364481/
https://www.ncbi.nlm.nih.gov/pubmed/35965599
http://dx.doi.org/10.3389/fnint.2022.957193
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author Tang, Qijun
Assali, Dina R.
Güler, Ali D.
Steele, Andrew D.
author_facet Tang, Qijun
Assali, Dina R.
Güler, Ali D.
Steele, Andrew D.
author_sort Tang, Qijun
collection PubMed
description How dopamine signaling regulates biological rhythms is an area of emerging interest. Here we review experiments focused on delineating dopamine signaling in the suprachiasmatic nucleus, nucleus accumbens, and dorsal striatum to mediate a range of biological rhythms including photoentrainment, activity cycles, rest phase eating of palatable food, diet-induced obesity, and food anticipatory activity. Enthusiasm for causal roles for dopamine in the regulation of circadian rhythms, particularly those associated with food and other rewarding events, is warranted. However, determining that there is rhythmic gene expression in dopamine neurons and target structures does not mean that they are bona fide circadian pacemakers. Given that dopamine has such a profound role in promoting voluntary movements, interpretation of circadian phenotypes associated with locomotor activity must be differentiated at the molecular and behavioral levels. Here we review our current understanding of dopamine signaling in relation to biological rhythms and suggest future experiments that are aimed at teasing apart the roles of dopamine subpopulations and dopamine receptor expressing neurons in causally mediating biological rhythms, particularly in relation to feeding, reward, and activity.
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spelling pubmed-93644812022-08-11 Dopamine systems and biological rhythms: Let’s get a move on Tang, Qijun Assali, Dina R. Güler, Ali D. Steele, Andrew D. Front Integr Neurosci Neuroscience How dopamine signaling regulates biological rhythms is an area of emerging interest. Here we review experiments focused on delineating dopamine signaling in the suprachiasmatic nucleus, nucleus accumbens, and dorsal striatum to mediate a range of biological rhythms including photoentrainment, activity cycles, rest phase eating of palatable food, diet-induced obesity, and food anticipatory activity. Enthusiasm for causal roles for dopamine in the regulation of circadian rhythms, particularly those associated with food and other rewarding events, is warranted. However, determining that there is rhythmic gene expression in dopamine neurons and target structures does not mean that they are bona fide circadian pacemakers. Given that dopamine has such a profound role in promoting voluntary movements, interpretation of circadian phenotypes associated with locomotor activity must be differentiated at the molecular and behavioral levels. Here we review our current understanding of dopamine signaling in relation to biological rhythms and suggest future experiments that are aimed at teasing apart the roles of dopamine subpopulations and dopamine receptor expressing neurons in causally mediating biological rhythms, particularly in relation to feeding, reward, and activity. Frontiers Media S.A. 2022-07-27 /pmc/articles/PMC9364481/ /pubmed/35965599 http://dx.doi.org/10.3389/fnint.2022.957193 Text en Copyright © 2022 Tang, Assali, Güler and Steele. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Tang, Qijun
Assali, Dina R.
Güler, Ali D.
Steele, Andrew D.
Dopamine systems and biological rhythms: Let’s get a move on
title Dopamine systems and biological rhythms: Let’s get a move on
title_full Dopamine systems and biological rhythms: Let’s get a move on
title_fullStr Dopamine systems and biological rhythms: Let’s get a move on
title_full_unstemmed Dopamine systems and biological rhythms: Let’s get a move on
title_short Dopamine systems and biological rhythms: Let’s get a move on
title_sort dopamine systems and biological rhythms: let’s get a move on
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364481/
https://www.ncbi.nlm.nih.gov/pubmed/35965599
http://dx.doi.org/10.3389/fnint.2022.957193
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