The Glycan-Binding Trait of the Sarbecovirus Spike N-Terminal Domain Reveals an Evolutionary Footprint

The spike protein on sarbecovirus virions contains two external, protruding domains: an N-terminal domain (NTD) with unclear function and a C-terminal domain (CTD) that binds the host receptor, allowing for viral entry and infection. While the CTD is well studied for therapeutic interventions, the r...

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Detalles Bibliográficos
Autores principales: Guo, Hua, Li, Ang, Lin, Hao-Feng, Liu, Mei-Qin, Chen, Jing, Jiang, Ting-Ting, Li, Bei, Wang, Yi, Letko, Michael C., Peng, Wenjie, Shi, Zheng-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Genetic Diversity and Evolution
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364788/
https://www.ncbi.nlm.nih.gov/pubmed/35852351
http://dx.doi.org/10.1128/jvi.00958-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364788/
https://www.ncbi.nlm.nih.gov/pubmed/35852351
http://dx.doi.org/10.1128/jvi.00958-22

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